Journal of Plastic Surgery and Hand Surgery https://medicaljournalssweden.se/JPHS <p>Journal of Plastic Surgery and Hand Surgery is as from 2023 an Open Access journal<em> s</em>erving as an international forum for plastic surgery, hand surgery, and related research. Interest is focused on original articles on basic research and clinical evaluation. The journal is published for the Acta Chirurgica Scandinavica Society, Sweden.</p> en-US <p>Acta Chirurgica Scandinavica Society owns the copyright for all material published until Volume 57 (2023) unless otherwise specified. As from Volume 59 (2024) all published articles, unless otherwise specified, are published under CC-BY licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, with the condition of proper attribution to the original work.<span class="Apple-converted-space"> </span></p> jphs@mjspublishing.se (Vera Fredriksson) jphs@mjspublishing.se (Vera Fredriksson) Mon, 01 Jan 2024 23:58:41 -0800 OJS 3.3.0.8 http://blogs.law.harvard.edu/tech/rss 60 The first dorsal metacarpal artery flaps versus reverse homodigital dorsal flaps for thumb reconstruction: a systematic review and meta-analysis https://medicaljournalssweden.se/JPHS/article/view/12435 <p class="p1"><strong>Purpose: </strong>This review was performed to systematically compare the effectiveness and safety of the first dorsal metacarpal artery flaps (FDMAF) and reverse homodigital dorsal flaps (RHDF) for thumb reconstruction.</p> <p class="p1"><strong>Methods: </strong>All literatures, which compared FDMAF versus RHDF for thumb reconstruction, were acquired through a comprehensive search in multiple databases from inception until 31st August 2022. A meta-analysis was performed using the Cochrane Collaboration’s RevMan 5.4 software.</p> <p class="p1"><strong>Results: </strong>A total of 19 articles were retrieved, comprising 396 patients in the FDMAF group and 423 patients in the RHDF group. The pooled estimates suggested that there were no significant differences in venous congestion, complications about flap necrosis and reduced range of motion (ROM) of thumb, static 2-point discrimination (S-2PD) between the two groups. On the other hand, patients in the RHDF group had less vascular crisis (odds ratio [OR] = 3.15, 95%CI, 1.31–7.56), complications about poor cortical reorientation (OR = 440.02, 95%CI, 91.97–2105.27) and higher satisfaction rate (OR = 0.56, 95% CI, 0.33–0.96) than those in the FDMAF group.</p> <p class="p1"><strong>Conclusions: </strong>The two surgical procedures were both safe and reliable since no significant differences were found in flap necrosis between the two groups. However, the patients in the RHDF group had less complications about vascular crisis, poor cortical reorientation and higher satisfaction rate. Accordingly, we thought RHDF may be more superior for thumb reconstruction than FDMAF.</p> Haifeng Shi, Yongjing Huang, Yong Shen, Ke Wu, Zhihai Zhang, Qian Li Copyright (c) 2024 Haifeng Shi, Yongjing Huang, Yong Shen, Ke Wu, Zhihai Zhang, Qian Li https://creativecommons.org/licenses/by/4.0 https://medicaljournalssweden.se/JPHS/article/view/12435 Mon, 26 Feb 2024 00:00:00 -0800 A systematic review of randomised controlled trials in breast reconstruction https://medicaljournalssweden.se/JPHS/article/view/40087 <p class="p1"><strong>Background: </strong>For preference sensitive treatments, such as breast reconstructions, there are barriers to conducting randomised controlled trials (RCTs). The primary aims of this systematic review were to investigate what type of research questions are explored by RCTs in breast reconstruction, where have they been performed and where have they been published, and to thematise the research questions and thus create an overview of the state of the research field.</p> <p class="p1"><strong>Methods:</strong> Randomised controlled trials investigating any aspect of breast reconstructions were included. The PubMed database was searched with a pre-defined search string. Inclusion and data abstraction was performed in a pre-defined standardised fashion. For the purpose of this study, we defined key issues as comparison of categories of breast reconstruction and comparison of immediate and delayed breast reconstruction, when the thematisation was done.</p> <p class="p1"><strong>Results:</strong> A total of 419 abstracts were retrieved from the search. Of the 419, 310 were excluded as they were not RCTs concerning some aspect of breast reconstruction, which left us with 110 abstracts to be included in the study. The research questions of the included studies could more or less be divided into seven different themes inclusive of 2 key issues: Other issues – comparison of different categories of breast reconstruction, comparison of immediate and delayed breast reconstruction, surgical details within a category of breast reconstruction, surgical details valid for several categories of breast reconstruction, donor site management, anaesthetics, and non-surgical details. Only five studies compared key issues, and they all illustrate the challenges with RCTs in breast reconstruction.</p> <p class="p1"><strong>Conclusions:</strong> A total of 110 publications based on RCTs in breast reconstruction have been published. Seven themes of research questions could be identified. Only five studies have explored the key issues. Better scientific evidence is needed for the key issues in breast reconstruction, for example by implementing a new study design in the field.</p> Emma Hansson, Camilla Larsson, Alexandra Uusimäki, Karolina Svensson, Emmelie Widmark Jensen, Anna Paganini Copyright (c) 2024 Emma Hansson, Camilla Larsson, Alexandra Uusimäki, Karolina Svensson, Emmelie Widmark Jensen, Anna Paganini https://creativecommons.org/licenses/by/4.0 https://medicaljournalssweden.se/JPHS/article/view/40087 Wed, 15 May 2024 00:00:00 -0700 Effect of high-density fat combined with adipose stem cell glue on the success rate of facial filling and its clinical value https://medicaljournalssweden.se/JPHS/article/view/18683 <p class="p1">Facial fat grafting is a popular cosmetic procedure, and experts are increasingly endorsing the use of high-density fat with adipose stem cell glue for better results. This study aims to explore the effect of high-density fat combined with adipose stem cell glue on the success rate of facial filling and its clinical value. We conducted a randomized trial with 100 patients who underwent facial fat transplantation between August 2020 and August 2022. They were divided into two groups: a control group receiving traditional Coleman fat transplantation and an observation group receiving high-density fat with adipose stem cells. In the observation and control groups, the excellent and good rate was 98.00 and 80.00%. After 3 months of treatment, the thickness of frontal subcutaneous fat and temporal subcutaneous fat in the observation group was higher (<em>P</em> &lt; 0.05). Observation group retention of fat transplantation was noticeably higher 3 months after treatment (<em>P</em> &lt; 0.05). Three months after treatment, the VISIA (facial imaging system) scores of facial color spots, facial pores and facial wrinkles in the observation group were lower (<em>P</em> &lt; 0.05). After treatment, both groups indicated noticeable improvements in physiological functions, health status, social function, mental health, and somatic diseases compared to before treatment. Notably, the observation group had higher scores (<em>P</em> &lt; 0.05). The observation group had a lower complication rate (4.00% vs. 22.00%) and higher satisfaction rate (98.00% vs. 86.00%) than the control group. Using high-density fat combined with adipose stem cell glue for facial fat grafting yields superior results, reduces complications, and boosts patient satisfaction compared to traditional methods. We have complied with all relevant ethical regulations with regard to the use of stem cells.</p> Junsheng Xu, Yu Zhao Copyright (c) 2024 Junsheng Xu, Yu Zhao https://creativecommons.org/licenses/by/4.0 https://medicaljournalssweden.se/JPHS/article/view/18683 Wed, 13 Mar 2024 00:00:00 -0700 Treatment and rehabilitation of post-traumatic elbow stiffness with heterotopic ossification https://medicaljournalssweden.se/JPHS/article/view/18363 <p class="p1"><strong>Aim:</strong> To investigate surgical treatment, postoperative rehabilitation and prevention of heterotopic ossification (HO) in patients with post-traumatic elbow stiffness.</p> <p class="p2"><strong>Methods:</strong> We performed a retrospective review of patients with post-traumatic elbow stiffness combined with HO between 2007 and 2021. This study was performed on a total of 15 patients (18 elbows) admitted to our hospital, consisting of 12 males and 3 females, with post-traumatic stiffness of the elbow combined with HO, where elbow function could not be recovered by rehabilitation and orthosis treatment. Fifteen patients were treated by surgical excision of heterotopic bones and release of elbow contracture combined with postoperative rehabilitation and orthosis-wearing. Comprehensive treatments, including radiation, oral ibuprofen medication, and manipulation techniques to improve range of motion, were used to prevent HO recurrence. The flexion–extension arc and functional score of the elbow were measured after treatment and compared with the preoperative measurements. Roentgenography was used to observe HO recurrence.</p> <p class="p1"><strong>Results:</strong> After surgical treatment and postoperative rehabilitation, the patients’ range of motion improved, and the functional score improved considerably. The postoperative flexion-extension arc and The Hospital for Special Surgery (HSS) functional score were statistically significantly higher than the preoperative values (<em>p</em> &lt; 0.01). Roentgenographic examination showed no HO recurrence during the follow-up period.</p> <p class="p1"><strong>Conclusion:</strong> Surgical excision of heterotopic bones and elbow contracture release combined with postoperative rehabilitation and preventative HO measures can be an effective treatment for cases of post-traumatic elbow stiffness combined with HO, for which conservative treatment is ineffective.</p> Qi Wang , Jiang Peng , Aiyuan Wang , Wenjing Xu , Jinshu Tang, Jinshu Tang Copyright (c) 2024 Qi Wang , Jiang Peng , Aiyuan Wang , Wenjing Xu , Jinshu Tang, Jinshu Tang https://creativecommons.org/licenses/by/4.0 https://medicaljournalssweden.se/JPHS/article/view/18363 Sun, 04 Feb 2024 00:00:00 -0800 Retrospective analysis of scaphoid trapezium pyrocarbon implant intervention in STT arthritis: a 3-year follow-up study https://medicaljournalssweden.se/JPHS/article/view/34985 <p class="p1"><strong>Aim: </strong>The purpose of this study was to evaluate clinical, patient rated and radiological outcome of the scaphoid trapezium pyrocarbon implant (STPI) at a minimum of three years follow-up.</p> <p class="p1"><strong>Methods: </strong>Consecutive patients operated with the STPI due to scaphotrapeziotrapezoidal (STT) arthritis between 2012 and 2019 were included. Patients were evaluated preoperatively and annually after surgery for range of motion, grip strength, key pinch, quick-DASH, pain, and satisfaction. Radiographs were evaluated for implant position, signs of dorsal intercalated segment instability (DISI), capitolunate (CL) angle, scapholunate (SL) distance, and presence of osteophytes.</p> <p class="p1"><strong>Results: </strong>Twenty-six patients (29 implants) were included. Seven implants were revised during the follow up, mainly due to pain: three implants were removed, four patients received a new STPI of a different size, leaving 22 implants in 20 patients available for follow up, 9 males and 11 females. Median age was 61.7 years (51–78 years). Median follow-up time was 68 months (37–105 months). Comparing preoperative status to the last follow-up, wrist extension and deviation, thumb abduction, and grip strength did not change. Key Pinch, quick DASH, pain, and patient satisfaction improved significantly at last follow-up. Radiographic signs of DISI were seen in six cases preoperatively and in 12 cases at last follow-up.</p> <p class="p1"><strong>Conlusion: </strong>At a minimum of three years follow-up, the STPI used for STT-arthritis improve pain, quick-DASH result, and patient satisfaction significantly. ROM and grip strength did not change compared to preoperative values. Radiographic signs of carpal instability were common at the follow-up and the revision rate was high.</p> Maria Zander, Allan Ibsen-Sörensen, Anders Nilsson, Anders Björkman Copyright (c) 2024 Maria Zander, Allan Ibsen-Sörensen, Anders Nilsson, Anders Björkman https://creativecommons.org/licenses/by/4.0 https://medicaljournalssweden.se/JPHS/article/view/34985 Tue, 02 Apr 2024 00:00:00 -0700 Entrapment of median nerve after elbow fracture dislocations: expected surgical time frame based on cadaver study https://medicaljournalssweden.se/JPHS/article/view/15323 <p class="p1"><strong>Introduction:</strong> Median nerve injuries occur in approximately 3% of pediatric elbow fracture dislocations. These rare injuries can be difficult to diagnose, and the results are poor in delay cases. Surgical timing is one of the most important prognostic factors. We aimed to present three patients with median nerve palsy who were referred to our clinic late, and according to these cases, we emphasized the expected time frame for exploration based on our anatomical cadaver study.</p> <p class="p1"><span class="s1"><strong>Materials and Methods:</strong> Between 2008 and 2010, three patients were referred to our clinic because of median nerve paralysis after a treated elbow dislocation. The mean interval between injury and referral was 15 (min: 13–max: 18) months, and the mean age of the patients was 15 (13–18) years. Neurolysis was performed in two patients, and for the third patent, after neurolysis, axonal continuity was observed to be disrupted so sural nerve grafting was performed with four cables. Tendon transfers were performed in all patients. A total number of 20 upper extremities of 10 cadavers were dissected. Due to its proximal innervation and ease of assessment, the muscle innervation of the flexor pollicis longus (FPL) was planned to be evaluated. The distance from the medial epicondyle is calculated in the cadaver study where the nerve injury is found.</span></p> <p class="p1"><strong>Results:</strong> The mean length from the medial epicondyle to the motor innervation of FPL was calculated in each specimen and found to be 101.99 millimeters (mm) (range: 87.5–134.2). The mean longest innervation of FPL was 110.83 mm from (range 87.5–148.1) the medial epicondyle calculated by including each specimens longest nerve length. Knowing that the healing time of a nerve lesion is 1 mm per day, we calculated that the recovery of FPL would take approximately 4 months.</p> <p class="p1"><strong>Conclusion:</strong> When nerve healing is expected to be 1 mm a day in axonotmesis type injury, after the median nerve palsy following elbow dislocation, thumb flexion should be achieved in the following 4 months generally if the nerve was not entrapped in the joint. This cadaver-based study objectively defined how long to wait for the innervation of the FPL in median nerve injuries in elbow fracture dislocations.</p> Yener Yoğun, Uğur Bezirgan, Tülin ŞEN ESMER, Sırrı Sinan Bilgin, Mehmet Armangil Copyright (c) 2024 Yener Yoğun, Uğur Bezirgan, Tülin ŞEN ESMER, Sırrı Sinan Bilgin, Mehmet Armangil https://creativecommons.org/licenses/by-nc/4.0 https://medicaljournalssweden.se/JPHS/article/view/15323 Thu, 18 Jan 2024 00:00:00 -0800 Systematic review of cost-effectiveness in breast reconstruction: deep inferior epigastric perforator flap vs. implant-based breast reconstruction https://medicaljournalssweden.se/JPHS/article/view/19649 <p><strong>Background:</strong> There are several techniques for reconstructing breasts after mastectomy, but little scientific evidence for which technique is superior. The aim of this systematic review was to compare the cost-effectiveness of implant-based and autologous reconstruction and to evaluate the overall certainty of evidence, as well as the quality of reporting of the included studies.</p> <p><strong>Methods:</strong> Studies investigating the cost-effectiveness of breast reconstruction with a deep inferior epigastric perforator (DIEP) flap compared to implant-based reconstruction, meeting criteria defined in a PICO (population, intervention, comparison, and outcome), were included. Medline, PubMed, Embase, Cochrane library, CinahL, EconLit, and NHS EED databases were searched. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence, and the Consolidated Health Economic Evaluation Reporting Standard (CHEERS) 2022 was used to evaluate the quality of reporting.</p> <p><strong>Results and conclusions:</strong> A total of 256 abstracts were retrieved from the search, and after scrutiny, seven studies were included. The findings of this present systematic review should be interpreted with caution as the overall certainty of evidence is low (GRADE ƟƟОО). The included studies suggest that DIEP-flaps are cost-effective compared with implant-based breast reconstruction when the applied cost-effectiveness thresholds of $50,000 to $100,000 per quality-adjusted life years are used. It is noteworthy that no high level evidence exists regarding cost-effeciency, to support recommendations and decision in breast reconstruction. Methodological issues that can be improved in future studies are presented.</p> Emma Hansson, Fredrik Brorson, Jonas Löfstrand, Anna Elander, Mikael Svensson Copyright (c) 2024 Emma Hansson, Fredrik Brorson, Jonas Löfstrand, Anna Elander, Mikael Svensson http://creativecommons.org/licenses/by/4.0/ https://medicaljournalssweden.se/JPHS/article/view/19649 Mon, 08 Jan 2024 00:00:00 -0800 Autologous fat transplantation prior to permanent expander implant breast reconstruction enhances the outcome after two years: a randomized controlled trial https://medicaljournalssweden.se/JPHS/article/view/18622 <p class="p1">Radiotherapy is important in breast cancer treatment. A side effect of the treatment is fibrosis that decreases the possibility for a successful breast reconstruction with expanders and with high patient satisfaction with the result. The most common option for mastectomized, irradiated women wishing for a breast reconstruction is autologous tissue transplantation. However, some patients are not suitable for flap surgery. Fifty mastectomized and irradiated women were included in a randomized controlled trial. They underwent breast reconstruction with expanders and were allocated 1:1 to either receive pre-treatment with autologous fat transplantation (AFT) or not. Primary outcomes were frequency of reoperations and complications. Secondary outcomes were number of days in hospital, number of outpatient visits to surgeon or nurse and patient reported outcome as reported with Breast Q. Follow-up time was 2 years. Fifty-two per cent of the intervention group and 68% of the controls underwent reoperations (<em>p</em> = 0.611). Thirty-two per cent of the intervention group and 52% of the controls had complications (<em>p</em> = 0.347). The median number of consultations with the nurse was four in the intervention group and six in the control group (<em>p</em> = 0.002). The AFT patients were significantly more satisfied with their breasts and psychosocial well-being after 2 years. They also had higher increase in satisfaction with breasts, psychosocial well-being, and sexual well-being when comparing baseline with 2 years postoperatively. This randomized controlled trial indicates benefits of AFT prior to breast reconstruction with expanders, especially on patient reported outcome even if the study sample is small.</p> Anna Lindegren, Inkeri Schultz, Åsa Edsander-Nord, Jacinth Yan, Marie Wickman Copyright (c) 2024 Anna Lindegren, Inkeri Schultz, Åsa Edsander-Nord, Jacinth Yan, Marie Wickman https://creativecommons.org/licenses/by/4.0 https://medicaljournalssweden.se/JPHS/article/view/18622 Mon, 20 May 2024 00:00:00 -0700 Improving standard volar plate fixation in 3D-guided corrective osteotomy of the distal radius: evaluation of a shim instrument https://medicaljournalssweden.se/JPHS/article/view/39839 <p class="p1"><span class="s1">Standard volar plates often do not fit the surface of the malunited distal radius after osteotomy, necessitating an offset angle for accurate volar tilt correction. The correction can be achieved if the plate is held at the correct angle when the distal screws are locked. With the advantage of 3D surgical planning and patient-specific instruments, we developed a shim instrument to assist the surgeon in securing the plate at the intended angle when locking the distal screws, and evaluated radiological results. Five female patients aged 63–74 with dorsally angulated extra-articular malunions underwent surgery using 3D-printed guides and the shim instrument. The plate position, drilling guide alignment, screw placements, and distal radius correction on postoperative CTs were compared with the surgical plans. Errors were measured using an anatomical coordinate system, and standard 2D radiographic measures were extracted. Preoperative dorsal tilt ranged from 16° to 35°, and postoperative volar tilt from 1° to 11°. 3D analysis revealed mean absolute correction errors of 6.1° in volar tilt, 1.6° in radial inclination, and 0.6 mm in ulnar variance. The volar tilt error due to the shim instrument, indicated by the mean angle error of the distal screws to the plate, was 2.1° but varied across the five patients. Settling of the distal radius, due to tension during and after reduction, further contributed to a mean loss of 3.5° in volar tilt. The shim instrument helped with securing plates at the intended angle; however, further correction improvements should consider the tension between the fragments of osteoporotic bone.</span></p> Emilia Gryska, Katleen Libberecht, Charlotte Stor Swinkels, Peter Axelsson, Per Fredrikson, Anders Björkman Copyright (c) 2024 Emilia Gryska, Katleen Libberecht, Charlotte Stor Swinkels, Peter Axelsson, Per Fredrikson, Anders Björkman https://creativecommons.org/licenses/by/4.0 https://medicaljournalssweden.se/JPHS/article/view/39839 Wed, 15 May 2024 00:00:00 -0700 Proximal row carpectomy versus four-corner arthrodesis: a retrospective comparative study https://medicaljournalssweden.se/JPHS/article/view/18338 <p class="p1"><strong>Background:</strong> Four-corner arthrodesis with scaphoid excision (FCA) and proximal row carpal resection (PRC) are frequently performed in wrists with post-traumatic Scaphoid Non- Union Advanced Collapse (SNAC)/Scapho-Lunate Advanced Collapse (SLAC) osteoarthritis. The aim of this study was to compare the clinical outcomes of these two procedures.</p> <p class="p1"><strong>Methods:</strong> This single-center, retrospective cohort study included all patients who had PRC or FCA between January 1st, 2009 and January 1st, 2019 and who were followed up. Follow-up included: mobility (radial deviation, ulnar deviation, flexion, extension), strength (grip test, pinch test), function (QuickDash, patient-rated wrist evaluation [PRWE]), subjective mobility, and global satisfaction scores.</p> <p class="p1"><strong>Results:</strong> Among 25 patients included, 11 had PRC and 14 had FCA with a mean follow-up of 69.5 months [12–132]. Radial deviation was 18° versus 14° (<em>p</em> = 0.7), ulnar deviation was 21° versus 22° (<em>p</em> = 0.15), flexion was 39° versus 30° (<em>p</em> = 0.32), extension was 32.5° versus 29.5° (<em>p</em> = 0.09), grip test compared to the controlateral side was 72% versus 62% (<em>p</em> = 0.53), Quick Dash score was 12.5 versus 17.6 (<em>p</em> = 0.84), PRWE was 18.7 versus 17.6 (<em>p</em> = 0.38), subjective mobility was 7.8 versus 7.5 (<em>p</em> = 0.23), and satisfaction score was 8.7 versus 9 (<em>p</em> = 0.76), respectively, in the FCA group and the PRC group. Re-operation rates were 14% patients in the FCA group and 0% in the PRC group.</p> <p class="p1"><strong>Conclusion:</strong> This study found no significant difference between FCA and PRC on strength, mobility, and function in patients with post-traumatic SLAC or SNAC stage II wrist arthritis. Both FCA and PRC seem to be reliable surgical techniques with good outcomes with more revision in the FCA group.</p> Richard Chan, Justine Goursat, Mathilde Payen, Matthieu Lalevée, Kamel Guelmi Copyright (c) 2024 Richard Chan, Justine Goursat, Mathilde Payen, Matthieu Lalevée, Kamel Guelmi https://creativecommons.org/licenses/by/4.0 https://medicaljournalssweden.se/JPHS/article/view/18338 Mon, 20 May 2024 00:00:00 -0700 Limited debridement combined with ReCell® Techniques for deep second-degree burns https://medicaljournalssweden.se/JPHS/article/view/24557 <p class="p1"><span class="s1"><strong>Background:</strong> The purpose of this article is to introduce a method that combines limited debridement and ReCell<sup>®</sup> autologous cell regeneration techniques for the treatment of deep second-degree burn wounds. </span></p> <p class="p1"><span class="s2"><strong>Method:</strong> A total of 20 patients suffered with deep second-degree burns less than 10% of total body surface area (TBSA) who were admitted to our department, from June 2019 to June 2021, participated in this study. These patients first underwent limited debridement with an electric/pneumatic dermatome, followed by the ReCell<sup>®</sup> technique for secondary wounds. Routine treatment was applied to prevent scarring after the wound healed. Clinical outcomes were scored using the Vancouver Scar Scale (VSS).</span></p> <p class="p1"><span class="s2"><strong>Results: </strong>All wounds of the patients healed completely. One patient developed an infection in the skin graft area and finally recovered by routine dressing changes. The average healing time was 12 days (range: 10–15 days). The new skin in the treated area was soft and matched the colour of the surrounding normal skin and the VSS score ranged from 3~5 for each patient. Of the 20 patients, 19 were very satisfied and 1 was satisfied. </span></p> <p class="p1"><strong>Conclusions: </strong>This article reports a useful treatment method that combines electric dermatome-dependent limited debridement and the ReCell<sup>® </sup>technique for the treatment of deep second-degree burn wounds. It is a feasible and effective strategy that is easy to implement and minimally invasive, and it is associated with a short healing time, mild scar formation and little damage to the donor skin area.</p> Yue Zhang, Kai Guo, Chenyang Tian, Ling Tong, Dahai Hu, Yunchuan Wang Copyright (c) 2024 Yue Zhang, Kai Guo, Chenyang Tian, Ling Tong, Dahai Hu, Yunchuan Wang https://creativecommons.org/licenses/by/4.0 https://medicaljournalssweden.se/JPHS/article/view/24557 Mon, 20 May 2024 00:00:00 -0700