CORRESPONDENCE
Dan DANIELSSON
Department of Clinical Microbiology and Immunology, Division of Laboratory Medicine, University Hospital, Örebro, Sweden. E-mail: dan.g.danielsson@telia.com
Citation: Acta Derm Venereol 2024; 104: adv40731. DOI: https://doi.org/10.2340/actadv.v104.40731.
Copyright: © 2024 The Author(s). Published by MJS Publishing, on behalf of the Society for Publication of Acta Dermato-Venereologica. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/).
Published: Aug 5, 2024
The excellent review of the pandemic disease brought to Europe by Columbus at the end of the 15th century brings into question the nature of the microbes (1).
Whole-genome sequencing (WGS) has revolutionized Treponema pallidum research. WGS has also been combined with paleopathology and recently broadened and deepened by the development and applications of paleogenomics. The recent retrieval of ancient syphilis and yaws/bejel genomes indicate that they are old diseases, spreading in Europe before contacts with the New World (2). Circumstantial evidence in historic contextual perspectives further showed that the crew members of Columbus brought a highly contagious and virulent yaws/bejel treponematosis to Europe – recognized as the French sickness or the Pox – and that this became a very important contributor to the rampant onslaught of the late 15th century epidemic (2), by posterity considered as the first syphilis pandemic (1).
We appreciate the thoughtful and knowledgeable comments by Dr Danielsson.
Anders Vahlquist, on behalf of all authors.