Systemic Inflammation and Evidence of a Cardio-splenic Axis in Patients with Psoriasis
DOI:
https://doi.org/10.2340/00015555-2873Keywords:
positron emission tomography computed tomography, inflammation, spleen, psoriasis, vascular inflammation, atherosclerosisAbstract
The spleen is thought to play a role in atherosclerosis-associated immunity and cardiovascular research has indicated the existence of a cardio-splenic axis. The aim of this study was to assess splenic 18F-fluorodeoxyglucose uptake as a measure of systemic inflammation in patients with untreated psoriasis compared with historical controls assessed by positron emission tomography-computed tomography. Patients with moderate-to-severe psoriasis (n?=?12, age 61.4???4.1 years, 83% men, mean? Psoriasis Area Severity Index score of 14.5) and controls (n?=?23, age 60.4???4.5 years, 87% men) were included in the study. Splenic inflammation was measured using the background-corrected spleen-liver-ratio (SLR) based on mean standardized uptake values. Mean???SD SLR was increased in patients with psoriasis compared with controls (0.94???0.11 vs. 0.82???0.08; p?=?0.001). SLR was significantly associated with aortic inflammation. These results support the existence of systemic inflammation in patients with psoriasis, and provide the rationale for a mechanistic link between psoriasis-driven inflammation and cardiovascular comorbidity through a spleen-atherosclerotic axis.Downloads
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Copyright (c) 2018 Kasper F. Hjuler, Lars C. Gormsen, Mikkel H. Vendelbo, Alexander Egeberg, Jakob Nielsen, Lars Iversen
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