Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch
DOI:
https://doi.org/10.2340/actadv.v103.4463Keywords:
psoriasis, pruritus, scalp psoriasisAbstract
Scalp psoriatic itch is a common, bothersome, yet understudied, condition with numerous associated treatment challenges. The aim of this study was to enhance our understanding of the pathophysiology of scalp psoriatic itch. Immunohistochemical analysis of known neuroimmune mediators of pruritus was conducted using scalp biopsies from 27 Hispanic psoriatic patients. Patients were categorized into mild/moderate or severe itch groups according to their itch intensity rating of scalp itch. Protease activated receptor (PAR2), substance P, transient receptor potential (TRP)V3, TRPM8 and interleukin-23 expression all correlated significantly with itch intensity. The pathophysiology of scalp psoriasis is largely non-histaminergic, mediated by PAR2, interleukin-23, transient receptor potential channels, and substance P.
Downloads
References
Prignano F, Ricceri F, Pescitelli L, et al. Itch in psoriasis: epidemiology, clinical aspects and treatment options. Clin Cosmet Investig Dermatol 2009; 2: 9-13.
https://doi.org/10.2147/CCID.S4465 DOI: https://doi.org/10.2147/CCID.S4465
Yosipovitch G, Goon A, Wee J, Chan YH, Goh CL. The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis. Br J Deramtol 2000; 143: 969-973.
https://doi.org/10.1046/j.1365-2133.2000.03829.x DOI: https://doi.org/10.1046/j.1365-2133.2000.03829.x
Dickison P, Swain G, Peek JJ, Smith SD. Itching for answers: prevalence and severity of pruritus in psoriasis. Australas J Dermatol 2018; 59: 206-209.
https://doi.org/10.1111/ajd.12747 DOI: https://doi.org/10.1111/ajd.12747
Szepietowski JC, Reich A, Wiśnicka B. Itching in patients suffering from psoriasis. Acta Dermatovenerol Croat 2002; 10: 221-226.
Stull C, Grossman S, Yosipovitch G. Current and emerging therapies for itch management in psoriasis. Am J Clin Dermatol 2016; 17: 617-624.
https://doi.org/10.1007/s40257-016-0213-5 DOI: https://doi.org/10.1007/s40257-016-0213-5
Hawro M, Sahin E, Steć M, Różewicka-Czabańska M, Raducha E, Garanyan L, Pet al. A comprehensive, tri-national, cross-sectional analysis of characteristics and impact of pruritus in psoriasis. J Eur Acad Dermatol Venereol 2022; 36: 2064-2075.
https://doi.org/10.1111/jdv.18330 DOI: https://doi.org/10.1111/jdv.18330
Leon A, Rosen JD, Hashimoto T, Fostini AC, Paus R, Yosipovitch G. Itching for an answer: a review of potential mechanisms of scalp itch in psoriasis. Exp Dermatol 2019; 28: 1387-1404.
https://doi.org/10.1111/exd.13947 DOI: https://doi.org/10.1111/exd.13947
Nattkemper LA, Tey HL, Valdes-Rodriguez R, Lee H, Mollanazar NK, Albornoz C, et al. The genetics of chronic itch: gene expression in the skin of patients with atopic dermatitis and psoriasis with severe itch. J Invest Dermatol 2018; 138: 1311-1317.
https://doi.org/10.1016/j.jid.2017.12.029 DOI: https://doi.org/10.1016/j.jid.2017.12.029
Yosipovitch G, Rosen JD, Hashimoto T. Itch: from mechanism to (novel) therapeutic approaches. J Allergy Clin Immunol 2018; 142: 1375-1390.
https://doi.org/10.1016/j.jaci.2018.09.005 DOI: https://doi.org/10.1016/j.jaci.2018.09.005
Bin Saif GA, Ericson ME, Yosipovitch G. The itchy scalp - scratching for an explanation. Exp Dermatol 2011; 20: 959-968.
https://doi.org/10.1111/j.1600-0625.2011.01389.x DOI: https://doi.org/10.1111/j.1600-0625.2011.01389.x
Amatya B, El-Nour H, Holst M, Theodorsson E, Nordlind K. Expression of tachykinins and their receptors in plaque psoriasis with pruritus. Br J Dermatol 2011; 164: 1023-1029.
https://doi.org/10.1111/j.1365-2133.2011.10241.x DOI: https://doi.org/10.1111/j.1365-2133.2011.10241.x
Jiang WY, Raychaudhuri SP, Farber EM. Double-labeled immunofluorescence study of cutaneous nerves in psoriasis. Int J Dermatol 1998; 37: 572-574.
https://doi.org/10.1046/j.1365-4362.1998.00533.x DOI: https://doi.org/10.1046/j.1365-4362.1998.00533.x
Kim TW, Shim WH, Kim JM, Mun JH, Song M, Kim HS, et al. Clinical characteristics of pruritus in patients with scalp psoriasis and their relation with intraepidermal nerve fiber density. Ann Dermatol 2014; 26: 727-732.
https://doi.org/10.5021/ad.2014.26.6.727 DOI: https://doi.org/10.5021/ad.2014.26.6.727
Pariser DM, Bagel J, Lebwohl M, Yosipovitch G, Chien E, Spellman MC. Serlopitant for psoriatic pruritus: a phase 2 randomized, double-blind, placebo-controlled clinical trial. J Am Acad Dermatol 2020; 82: 1314-1320.
https://doi.org/10.1016/j.jaad.2020.01.056 DOI: https://doi.org/10.1016/j.jaad.2020.01.056
Azimi E, Reddy VB, Pereira PJS, Talbot S, Woolf CJ, Lerner EA. Substance P activates Mas-related G protein-coupled receptors to induce itch. J Allergy Clin Immunol 2017; 140: 447-453.e3.
https://doi.org/10.1016/j.jaci.2016.12.980 DOI: https://doi.org/10.1016/j.jaci.2016.12.980
Petersen LJ, Hansen U, Kristensen JK, Nielsen H, Skov PS, Nielsen HJ. Studies on mast cells and histamine release in psoriasis: the effect of ranitidine. Acta Derm Venereol 1998; 78: 190-193.
https://doi.org/10.1080/000155598441503 DOI: https://doi.org/10.1080/000155598441503
Zhang Y, Shi Y, Lin J, Li X, Yang B, Zhou J. Immune cell infiltration analysis demonstrates excessive mast cell activation in psoriasis. Front Immunol 2021; 12: 773280.
https://doi.org/10.3389/fimmu.2021.773280 DOI: https://doi.org/10.3389/fimmu.2021.773280
Sun, S, Dong, X. Trp channels and itch. Semin Immunopathol 2016; 38: 293-307.
https://doi.org/10.1007/s00281-015-0530-4 DOI: https://doi.org/10.1007/s00281-015-0530-4
Wilson SR, Bautista DM. Role of transient receptor potential channels in acute and chronic itch. In: Carstens E, Akiyama T, editors. Itch: mechanisms and treatment. Boca Raton, FL: CRC Press/Taylor & Francis; 2014, chapter 16.
Bernstein JE, Parish LC, Rapaport M, Rosenbaum MM, Roenigk Jr HH. Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris. J Am Acad Deramtol 1986; 15: 504-507.
https://doi.org/10.1016/S0190-9622(86)70201-6 DOI: https://doi.org/10.1016/S0190-9622(86)70201-6
Ellis CN, Berberian B, Sulica VI, Dodd WA, Jarratt MT, Katz HI, et al. A double-blind evaluation of topical capsaicin in pruritic psoriasis. J Am Acad Dermatol. J Am Acad Dermatol 1993; 29: 438-442.
https://doi.org/10.1016/0190-9622(93)70208-B DOI: https://doi.org/10.1016/0190-9622(93)70208-B
Xie Z, Hu H. TRP channels as drug targets to relieve itch. Pharmaceuticals (Basel) 2018; 11: 100.
https://doi.org/10.3390/ph11040100 DOI: https://doi.org/10.3390/ph11040100
Patel T, Ishiuji Y, Yosipovitch G. Menthol: a refreshing look at this ancient compound. J Am Acad Dermatol 2007; 57: 873-878.
https://doi.org/10.1016/j.jaad.2007.04.008 DOI: https://doi.org/10.1016/j.jaad.2007.04.008
Ruano J, Suárez-Fariñas M, Shemer A, Oliva M, Guttman-Yassky E, Krueger JG. Molecular and cellular profiling of scalp psoriasis reveals differences and similarities compared to skin psoriasis. PLoS One 2016; 11: e0148450.
https://doi.org/10.1371/journal.pone.0148450 DOI: https://doi.org/10.1371/journal.pone.0148450
Narbutt J, Olejniczak I, Sobolewska-Sztychny D, Sysa-Jedrzejowska A, Stowik-Kwiatkowska I, Hawro T, et al. Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients. Arch Dermatol Res 2013; 305: 191-195.
https://doi.org/10.1007/s00403-012-1293-6 DOI: https://doi.org/10.1007/s00403-012-1293-6
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2023 Leigh A. Nattkemper, Zoe M. Lipman, Giuseppe Ingrasci, Claudia Maldonado, Juan Carlos Garces, Enrique Loayza; Gil Yosipovitch
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.
Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.
