@article{Yoon Jung_Hoon Kwon_Soo Hong_Young Yoon_Sun Park_Young Jang_Hun Suh_2014, title={Effect of Dietary Supplementation with Omega-3 Fatty Acid and Gamma-linolenic Acid on Acne Vulgaris: A Randomised, Double-blind, Controlled Trial}, volume={94}, url={https://medicaljournalssweden.se/actadv/article/view/6412}, DOI={10.2340/00015555-1802}, abstractNote={This study was undertaken to evaluate the clinical efficacy, safety, and histological changes induced by dietary omega-3 fatty acid and γ-linoleic acid in acne vulgaris. A 10-week, randomised, controlled parallel dietary intervention study was performed in 45 participants with mild to moderate acne, which were allocated to either an omega-3 fatty acid group (2,000 mg of eicosapentaenoic acid and docosahexaenoic acid), a γ-linoleic acid group (borage oil containing 400 mg γ-linoleic acid), or a control group. After 10 weeks of omega-3 fatty acid or γ-linoleic acid supplementation, inflammatory and non-inflammatory acne lesions decreased significantly. Patient subjective assessment of improvement showed a similar result. Heamatoxylin & eosin staining of acne lesions demonstrated reductions in inflammation and immunohistochemical staining intensity for interleukin-8. No severe adverse effect was reported. This study shows for the first time that omega-3 fatty acid and γ-linoleic acid could be used as adjuvant treatments for acne patients.}, number={5}, journal={Acta Dermato-Venereologica}, author={Yoon Jung, Jae and Hoon Kwon, Hyuck and Soo Hong, Jong and Young Yoon, Ji and Sun Park, Mi and Young Jang, Mi and Hun Suh, Dae}, year={2014}, month={Jan.}, pages={521–525} }