TY - JOUR AU - Gerner, Trine AU - Rasmussen Rinnov, Maria AU - Halling, Anne-Sofie AU - Haarup Ravn, Nina AU - Hjorslev Knudgaard, Mette AU - Ewertsen, Caroline AU - Trautner, Simon AU - Jakasa, Ivone AU - Kezic, Sanja AU - Skov, Lone AU - Thyssen, Jacob P. PY - 2022/06/15 Y2 - 2024/03/29 TI - Differences in Occurrence, Risk Factors and Severity of Early-onset Atopic Dermatitis among Preterm and Term Children JF - Acta Dermato-Venereologica JA - Acta Derm Venereol VL - 102 IS - SE - Articles DO - 10.2340/actadv.v102.575 UR - https://medicaljournalssweden.se/actadv/article/view/575 SP - adv00737 AB - <p class="p1">This prospective birth cohort followed 150 preterm and 300 term newborns during the first year of life to assess possible differences in risk factors, age at onset, anatomical location, and severity of atopic dermatitis. Atopic dermatitis was diagnosed clinically, and severity was assessed using Eczema Area Severity Index (EASI). DNA was analysed for filaggrin gene mutations. Parents were asked about environmental exposures and emollient use. Atopic dermatitis during the first year of life was observed in 21.2% of children and was more common in term children compared with preterm children (26.7% vs 11.7%, <em>p </em>&lt; 0.001), with lower age of onset (4 vs 6 months, <em>p </em>&lt; 0.05) and more severe disease at onset (EASI: 4.8 vs 0.4, <em>p </em>&lt; 0.0005). Environmental risk factors for atopic dermatitis were essentially similar for preterm and term born children, apart from winter and autumn births. <em>Filaggrin</em> gene mutations were less common in preterm than term children (4.1% vs 9.2%, <em>p </em>= 0.06).</p> ER -