Bottomley WW, Cunliffe WJ. Severe flares of acne following isotretinoin: large closed comedones (macrocomedones) are a risk factor. Acta Derm Venereol [Internet]. 1993 Feb. 1 [cited 2026 May 24];73(1):74. Available from: https://medicaljournalssweden.se/actadv/article/view/16472