% interactnlmsample.tex
% v1.05 - August 2017

\documentclass[]{interact}

\usepackage{graphicx}
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\usepackage{geometry}
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\usepackage{xcolor}
\usepackage{soul}
\usepackage{tabularx}
\usepackage{gensymb}


\begin{document}

\appendix

\section{Supplementary Material}

\begin{figure}[h]
\centering
\includegraphics[angle=90, width = 0.9\textwidth]{figureA1}
\caption{Figure of dose/volume measures for the pre-treatment robust evaluation associated with the planning computed tomography scan (pCT, scan 0) and the during-treatment robust evaluations associated with the weekly control computed tomography scans (cCTs, scans 1 to 6-8) for five patient. The red dashed lines mark the constraint values corresponding to the dose/volume measures. A circular dot signifies a nominal treatment plan with no distal edge uncertainty, a cross means that the value corresponds to a scenario with distal edge uncertainty +3.5\% and equivalently, a square signifies a -3.5\% distal edge uncertainty scenario. The figure is continued for five additional patients in Figure \ref{fig:res_5ptF-J}.}
\label{fig:res_5ptA-E}
\end{figure}


\begin{figure}[h]
\centering
\includegraphics[angle=90, width = 0.9\textwidth]{figureA2}
\caption{Figure continued from Figure \ref{fig:res_5ptA-E} with five additional patients.}
\label{fig:res_5ptF-J}
\end{figure}


\begin{figure}[h]
\centering
\includegraphics[width=\textwidth]{figureA3}
\caption{The figure show time trends in a specific dose/volume measure: The percentage of the volume of the primary clinical target volume that receives 95\% of the prescribed dose. This is denoted CTVp V95\%.
The figure displays the pre-treatment robust evaluation associated with the planning computed tomography scan (blue leftmost markers) and the during-treatment robust evaluations associated with the weekly control computed tomography scans (remaining markers, one colour for each week's scan) for ten patient. The red dashed lines mark the constraint values corresponding to the dose/volume measures. A circular dot signifies a nominal treatment plan with no distal edge uncertainty, a cross means that the value corresponds to a scenario with distal edge uncertainty +3.5\% and equivalently, a square signifies a -3.5\% distal edge uncertainty scenario.}
\label{fig:timetrendCTVp}
\end{figure}

\begin{figure}[h]
\centering
\includegraphics[width=\textwidth]{figureA4}
\caption{The figure show time trends in a specific dose/volume measure: The percentage of the volume of the elective clinical target volume that receives 95\% of the prescribed dose. This is denoted CTVe V95\%.
The figure displays the pre-treatment robust evaluation associated with the planning computed tomography scan (blue leftmost markers) and the during-treatment robust evaluations associated with the weekly control computed tomography scans (remaining markers, one colour for each week's scan) for ten patient. The red dashed lines mark the constraint values corresponding to the dose/volume measures. A circular dot signifies a nominal treatment plan with no distal edge uncertainty, a cross means that the value corresponds to a scenario with distal edge uncertainty +3.5\% and equivalently, a square signifies a -3.5\% distal edge uncertainty scenario.}
\label{fig:timetrendCTVe}
\end{figure}

\begin{figure}[h]
\centering
\includegraphics[width=\textwidth]{figureA5}
\caption{The figure show time trends in a specific dose/volume measure: The percentage of the volume of the rectum that receives 75 Gy. This is denoted rectum V75Gy.
The figure displays the pre-treatment robust evaluation associated with the planning computed tomography scan (blue leftmost markers) and the during-treatment robust evaluations associated with the weekly control computed tomography scans (remaining markers, one colour for each week's scan) for ten patient. The red dashed lines mark the constraint values corresponding to the dose/volume measures. A circular dot signifies a nominal treatment plan with no distal edge uncertainty, a cross means that the value corresponds to a scenario with distal edge uncertainty +3.5\% and equivalently, a square signifies a -3.5\% distal edge uncertainty scenario.}
\label{fig:timetrendRectum}
\end{figure}

\begin{figure}[h]
\centering
\includegraphics[width=\textwidth]{figureA6}
\caption{The figure show time trends in a specific dose/volume measure: The percentage of the volume of the bladder that receives 80 Gy. This is denoted bladder V80Gy.
The figure displays the pre-treatment robust evaluation associated with the planning computed tomography scan (blue leftmost markers) and the during-treatment robust evaluations associated with the weekly control computed tomography scans (remaining markers, one colour for each week's scan) for ten patient. The red dashed lines mark the constraint values corresponding to the dose/volume measures. A circular dot signifies a nominal treatment plan with no distal edge uncertainty, a cross means that the value corresponds to a scenario with distal edge uncertainty +3.5\% and equivalently, a square signifies a -3.5\% distal edge uncertainty scenario.}
\label{fig:timetrendBladder}
\end{figure}

\begin{figure}[h]
\centering
\includegraphics[width=\textwidth]{figureA7}
\caption{The figure show time trends in a specific dose/volume measure: The percentage of the volume of the bowel that receives 35 Gy. This is denoted bowel V35Gy.
The figure displays the pre-treatment robust evaluation associated with the planning computed tomography scan (blue leftmost markers) and the during-treatment robust evaluations associated with the weekly control computed tomography scans (remaining markers, one colour for each week's scan) for ten patient. The red dashed lines mark the constraint values corresponding to the dose/volume measures. A circular dot signifies a nominal treatment plan with no distal edge uncertainty, a cross means that the value corresponds to a scenario with distal edge uncertainty +3.5\% and equivalently, a square signifies a -3.5\% distal edge uncertainty scenario.}
\label{fig:timetrendBowel}
\end{figure}

\begin{table}[h]
\centering
\caption{Constraints for treatment planning. These were also used as robust evaluation dose/volume measures. The bowel constraint labelled 'optimal' was aimed for in treatment planning but was rarely achieved and was not included in the present analysis.}
\label{tab:constraints}
\begin{tabular}{ll}
\hline 
\textbf{Structure} & \textbf{Constraint} \\ 
\hline 
CTVp & V95\% $\geq$ 98\% \\ 
\hline 
CTVe & V95\% $\geq$ 98\% \\ 
\hline 
Rectum & V75Gy $\leq$ 3\% \\
 & V70Gy $\leq$ 15 \% \\
 & V65Gy $\leq$ 30\% \\
 & V50Gy $\leq$ 60\% \\
 & V40Gy $\leq$ 70\% \\
 & V30Gy $\leq$ 80\% \\ 
\hline 
Bladder & V80Gy $\leq$ 15\% \\
 & V70Gy $\leq$ 35\% \\
 & V65Gy $\leq$ 50\% \\ 
\hline 
Bowel & V35Gy $\leq$ 40\% \\
 & V45Gy $\leq$ 195 cm$^3$ (optimal) \\ 
\hline 
\end{tabular}
\end{table} 


\end{document}
