Limited adherence to growth hormone replacement in patients with traumatic brain injury
DOI:
https://doi.org/10.2340/20030711-1000008Keywords:
endocrinology, neuroendocrinology, traumatic brain injury, acquired brain injury.Abstract
Background: Growth hormone deficiency is a recognized consequence of traumatic brain injury. The aim of this study was to determine adherence to human growth hormone therapy among patients with traumatic brain injury compared with patients with hypothalamic or pituitary disease. Methods: A retrospective chart review of patients with traumatic brain injury referred for growth hormone stimulation testing since December 2013. Within the same electronic medical record, patients who were started on human growth hormone for aetiologies other than traumatic brain injury were reviewed. Adherence to therapy at 1-year follow-up was compared. Results: Of the patients with traumatic brain injury, 12/23 (52%) returned for follow-up at 1 year to continue human growth hormone treatment, whereas 11/23 (48%) did not return at 1 year. Amongst the patients with non-traumatic brain injury: 25/29 (86%) continued human growth hormone treatment, vs 4/29 (14%) who did not return. A higher proportion of patients with non-traumatic brain injury continued human growth hormone treat-ment; ?2 (1, n?=?52)p?=?7.238, p?=?0.007. Conclusion: There may be differences in the patient-perceived benefits of human growth hormone between these patient populations. However, it is important to consider the potential influences of cognitive and psychosocial dysfunction that can occur in patients with brain injuries.Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 Kirstie C. Lithgow, Chantel Debert, Gregory A. Kline
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles in JRM-CC are Open Access and, unless otherwise specified, distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). This license permits sharing, adapting, and using the material for any purpose, including commercial use, with the condition of providing full attribution to the original publication.