Incidence of vestibular schwannoma in Finland, 1990–2017
DOI:
https://doi.org/10.2340/1651-226X.2024.20352Keywords:
Neuroma, acoustic, cranial nerve neoplasms, incidence, epidemiology, FinlandAbstract
Background: An increasing trend in incidence of vestibular schwannomas (VS) has been reported, though not consistently, across populations.
Materials and methods: We obtained data from the Finnish Cancer Registry on 1,149 VS cases diagnosed in 1990–2017 with tabular data up to 2022. We calculated age-standardised incidence rates (ASR) overall, by sex, and for 10-year age groups. We analysed time trends using Poisson and joinpoint regression.
Results: The average ASR of VS in Finland during 1990–2017 was 8.6/1,000,000 person-years for women and 7.5/1,000,000 for men. A declining trend was found with an average annual percent change of −1.7% (95% confidence interval [CI]: −2.8%, −0.6%) for women, −2.2% (95% CI: −3.6%, −0.7%) for men, and −1.9% (95% CI: −2.9%, −1.0%) for both sexes combined. The ASR in women was 11.6/1,000,000 person-years in 1990 and it decreased to 8.2/1,000,000 by 2017. Correspondingly, the incidence in men was 7.1/1,000,000 in 1990 and decreased to 5.1/1,000,000 by 2017. Some decline in incidence over time was found in all age groups below 80 years, but the decline (2.3–3.1% per year) was statistically significant only in age groups 40–49, 50–59, and 60–69 years. In the oldest age group (80+ years), the incidence of VS increased by 16% per year. For 2018–2022, the ASR was 7.6/1,000,000 for both sexes combined, with a decline by −1.7% (95% CI: −2.3%, −1.2%) annually for the entire period 1990–2022.
Conclusion: In contrast to the increasing incidence reported in some studies, we found a decreasing trend in VS incidence for both sexes in Finland.
Downloads
References
Rosahl S, Bohr C, Lell M, Hamm K, Iro H. Diagnostics and therapy of vestibular schwannomas – an interdisciplinary challenge. GMS Curr Top Otorhinolaryngol Head Neck Surg. 2017;16:Doc03
Carlson ML, Link MJ. Vestibular schwannomas. N Engl J Med. 2021;384(14):1335–48. https://doi.org/10.1056/NEJMra2020394 DOI: https://doi.org/10.1056/NEJMra2020394
Peris-Celda M, Graffeo CS, Perry A, et al. Main symptom that led to medical evaluation and diagnosis of vestibular schwannoma and patient-reported tumor size: cross-sectional study in 1,304 patients. J Neurol Surg B Skull Base. 2019;80(3):316–22. https://doi.org/10.1055/s-0038-1675175 DOI: https://doi.org/10.1055/s-0038-1675175
Thapa PB, Shahi S, Jha RK, Shrestha D. Vestibular schwanomma: an experience in a developing world. World J Oncol. 2019;10(2):118–22. https://doi.org/10.14740/wjon1195 DOI: https://doi.org/10.14740/wjon1195
Goldbrunner R, Weller M, Regis J, et al. EANO guideline on the diagnosis and treatment of vestibular schwannoma. Neuro Oncol. 2020;22(1):31–45. https://doi.org/10.1093/neuonc/noz153 DOI: https://doi.org/10.1093/neuonc/noz153
Evans DG. Neurofibromatosis type 2 (NF2): a clinical and molecular review. Orphanet J Rare Dis. 2009;4:16. https://doi.org/10.1186/1750-1172-4-16 DOI: https://doi.org/10.1186/1750-1172-4-16
Asthagiri AR, Parry DM, Butman JA, et al. Neurofibromatosis type 2. Lancet. 2009;373(9679):1974–86. https://doi.org/10.1016/S0140-6736(09)60259-2 DOI: https://doi.org/10.1016/S0140-6736(09)60259-2
Schoemaker MJ, Swerdlow AJ, Ahlbom A, et al. Mobile phone use and risk of acoustic neuroma: results of the interphone case-control study in five north European countries. Br J Cancer. 2005;93(7):842–8. https://doi.org/10.1038/sj.bjc.6602764 DOI: https://doi.org/10.1038/sj.bjc.6602764
Schneider AB, Ron E, Lubin J, et al. Acoustic neuromas following childhood radiation treatment for benign conditions of the head and neck. Neuro Oncol. 2008;10(1):73–8. https://doi.org/10.1215/15228517-2007-047 DOI: https://doi.org/10.1215/15228517-2007-047
Chen M, Fan Z, Zheng X, Cao F, Wang L. Risk factors of acoustic neuroma: systematic review and meta-analysis. Yonsei Med J. 2016;57(3):776–83. https://doi.org/10.3349/ymj.2016.57.3.776 DOI: https://doi.org/10.3349/ymj.2016.57.3.776
Propp JM, McCarthy BJ, Davis FG, Preston-Martin S. Descriptive epidemiology of vestibular schwannomas. Neuro Oncol. 2006;8(1):1–11. https://doi.org/10.1215/S1522851704001097 DOI: https://doi.org/10.1215/S1522851704001097
Marinelli JP, Lohse CM, Carlson ML. Incidence of vestibular schwannoma over the past half-century: a population-based study of Olmsted County, Minnesota. Otolaryngol Head Neck Surg. 2018;159(4):717–23. https://doi.org/10.1177/0194599818770629 DOI: https://doi.org/10.1177/0194599818770629
Reznitsky M, Petersen M, West N, Stangerup S-E, Cayé-Thomasen P. Epidemiology of vestibular schwannomas – prospective 40-year data from an unselected national cohort. Clin Epidemiol. 2019;11:981–6. https://doi.org/10.2147/CLEP.S218670 DOI: https://doi.org/10.2147/CLEP.S218670
Marinelli JP, Lohse CM, Grossardt B, Lane JI, Carlson ML. Rising incidence of sporadic vestibular schwannoma: true biological shift versus simply greater detection. Otol Neurotol. 2020;41(6):813–47. https://doi.org/10.1097/MAO.0000000000002626 DOI: https://doi.org/10.1097/MAO.0000000000002626
Larjavaara S, Feychting M, Sankila R, et al. Incidence trends of vestibular schwannomas in Denmark, Finland, Norway and Sweden in 1987–2007. Br J Cancer. 2011;105(7):1069–75. https://doi.org/10.1038/bjc.2011.344 DOI: https://doi.org/10.1038/bjc.2011.344
Kshettry V, Hsieh J, Ostrom Q, Kruchko C, Barnholtz-Sloan JS. Incidence of vestibular schwannomas in the United States. J Neuro Oncol. 2015;124(2):223–8. https://doi.org/10.1007/s11060-015-1827-9 DOI: https://doi.org/10.1007/s11060-015-1827-9
Tos M, Charabi S, Thomsen J. Incidence of vestibular schwannomas. Laryngoscope. 1999;109(5):736–40. https://doi.org/10.1097/00005537-199905000-00011 DOI: https://doi.org/10.1097/00005537-199905000-00011
Stangerup S, Tos M, Caye-Thomasen P, Tos T, Klokker M, Thomsen J. Increasing annual incidence of vestibular schwannoma and age at diagnosis. J Laryngol Otol. 2004;118(8):622–7. https://doi.org/10.1258/0022215041917989 DOI: https://doi.org/10.1258/0022215041917989
Evans DG, Moran A, King A, Saeed S, Gurusinghe N, Ramsden R. Incidence of vestibular schwannoma and neurofibromatosis 2 in the North-West of England over a 10-year period: higher incidence than previously thought. Otol Neurol. 2005;26(1):93–7. https://doi.org/10.1097/00129492-200501000-00016 DOI: https://doi.org/10.1097/00129492-200501000-00016
Schmidt RF, Boghani Z, Choudhry OJ, Anderson Eloy J, Jyung RW, Liu JK. Incidental vestibular schwannomas: a review of prevalence, growth rate, and management challenges. Neurosurg Focus. 2012;33(3):E4. https://doi.org/10.3171/2012.7.FOCUS12186 DOI: https://doi.org/10.3171/2012.7.FOCUS12186
Leinonen MK, Miettinen J, Heikkinen S, Pitkäniemi J, Malila N. Quality measures of the population-based Finnish cancer registry indicate sound data quality for solid malignant tumours. Eur J Cancer. 2017;77:31–9. https://doi.org/10.1016/j.ejca.2017.02.017 DOI: https://doi.org/10.1016/j.ejca.2017.02.017
A Fritz, C Percy, A Jack, K Shanmugaratnam, L Sobin, DM Parkin et al. International classification of disease for oncology. 3rd ed. Geneva:WHO; 2000. 1st revision 2013.
WHO (World Health Organization) 1958. The International statistical classification of diseases, Seventh Revision. WHO, Geneva.
Moffat DA, Ballagh RH. Rare tumours of the cerebellopontine angle. Clin Oncol. 1995;7(1):28–41. https://doi.org/10.1016/S0936-6555(05)80632-6 DOI: https://doi.org/10.1016/S0936-6555(05)80632-6
PHS. European standard population by sex. [cited 2020 Aug 1]. Available from: https://www.opendata.nhs.scot/dataset/standard-populations/resource/29ce4cda-a831-40f4-af24-636196e05c1a Web site
PHS. World standard population. [cited 2021 Apr 15]. Available from: https://www.opendata.nhs.scot/dataset/standard-populations/resource/e27533df-a1c1-4a3c-b042-c59763751fba Web site
Tos M, Stangerup S, Cayé-Thomasen P, Tos T, Thomsen J. What is the real incidence of vestibular schwannoma? Arch Otolaryngol Head Neck Surg. 2004;130(2):216–20. https://doi.org/10.1001/archotol.130.2.216 DOI: https://doi.org/10.1001/archotol.130.2.216
Stangerup S, Tos M, Thomsen J, Cayé-Thomasen P. True incidence of vestibular schwannoma? Neurosurgery. 2010;67(5):1335–40. https://doi.org/10.1227/NEU.0b013e3181f22660 DOI: https://doi.org/10.1227/NEU.0b013e3181f22660
Kleijwegt M, Ho V, Visser O, Godefroy W, van der Mey A. Real incidence of vestibular schwannoma? estimations from a national registry. Otol Neurotol. 2016;37(9):1411–7. https://doi.org/10.1097/MAO.0000000000001169 DOI: https://doi.org/10.1097/MAO.0000000000001169
Cioffi G, Yeboa DN, Kelly M, et al. Epidemiology of vestibular schwannoma in the United States, 2004–2016. Neuro Oncol Adv. 2020;2(1):vdaa135. https://doi.org/10.1093/noajnl/vdaa135 DOI: https://doi.org/10.1093/noajnl/vdaa135
Koo M, Lai J, Yang EY, Liu T, Hwang J. Incidence of vestibular schwannoma in Taiwan from 2001 to 2012: a population-based national health insurance study. Ann Otol Rhinol Laryngol. 2018;127(10):694–7. https://doi.org/10.1177/0003489418788385 DOI: https://doi.org/10.1177/0003489418788385
Withrow DR, Devesa SS, Deapen D, et al. Non-malignant meningioma and vestibular schwannoma incidence trends in the United States, 2004–2017. Cancer. 2021;127:3579–90. https://doi.org/10.1002/cncr.33553 DOI: https://doi.org/10.1002/cncr.33553
de Robles P, Fiest KM, Frolkis AD, et al. The worldwide incidence and prevalence of primary brain tumors: a systematic review and meta-analysis. Neuro Oncol. 2014;17(6):776–83. https://doi.org/10.1093/neuonc/nou283 DOI: https://doi.org/10.1093/neuonc/nou283
Marinelli JP, Nassiri AM, Habermann EB, Lohse CM, Holton SJ, Carlson ML. Underreporting of vestibular schwannoma incidence within National Brain Tumor and Cancer Registries in the United States. Otol Neurotol. 2021;42:e758–63. https://doi.org/10.1097/MAO.0000000000003049 DOI: https://doi.org/10.1097/MAO.0000000000003049
Fernández-Méndez R, Wan Y, Axon P, Joannides A. Incidence and presentation of vestibular schwannoma: a 3-year cohort registry study. Acta Neurochir. 2023;165(10):2903–11. https://doi.org/10.1007/s00701-023-05665-9 DOI: https://doi.org/10.1007/s00701-023-05665-9
Marinelli JP, Beeler CJ, Carlson ML, Cayé-Thomasen P, Spear SA, Erbele ID. Global Incidence of sporadic vestibular schwannoma: a systematic review. Otolaryngol Head Neck Surg. 2022 Aug;167(2):209–14. https://doi.org/10.1177/01945998211042006 DOI: https://doi.org/10.1177/01945998211042006
FCR. Description of statistics and their quality. [cited 2020 Sep 2]. Available from: https://cancerregistry.fi/statistics/statistical-descriptions-quality-reports/ Web site
Published
How to Cite
License
Copyright (c) 2024 Aino Iivanainen, Jani Raitanen, Anssi Auvinen
This work is licensed under a Creative Commons Attribution 4.0 International License.
