Repeatability of hypoxia dose painting by numbers based on EF5-PET in head and neck cancer

Abstract

Background

Hypoxia dose painting is a radiotherapy technique to increase the dose to hypoxic regions of the tumour. Still, the clinical effect relies on the reproducibility of the hypoxic region shown in the medical image. ¹⁸F-EF5 is a hypoxia tracer for positron emission tomography (PET), and this study investigated the repeatability of ¹⁸F-EF5-based dose painting by numbers (DPBN) in head and neck cancer (HNC).

Materials and methods

Eight HNC patients undergoing two ¹⁸F-EF5-PET/CT sessions (A and B) before radiotherapy were included. A linear conversion of PET signal intensity to radiotherapy dose prescription was employed and DPBN treatment plans were created using the image basis acquired at each PET/CT session. Also, plan A was recalculated on the image basis for session B. Voxel-by-voxel Pearson’s correlation and quality factor were calculated to assess the DPBN plan quality and repeatability.

Results

The mean (SD) correlation coefficient between DPBN prescription and plan was 0.92 (0.02) and 0.93 (0.02) for sessions A and B, respectively, with corresponding quality factors of 0.02 (0.002) and 0.02 (0.003), respectively. The mean correlation between dose prescriptions at day A and B was 0.72 (0.13), and 0.77 (0.12) for the corresponding plans. A mean correlation of 0.80 (0.08) was found between plan A, recalculated on image basis B, and plan B.

Conclusion

Hypoxia DPBN planning based on ¹⁸F-EF5-PET/CT showed high repeatability. This illustrates that ¹⁸F-EF5-PET provides a robust target for dose painting.