Effect of Surgery on Normal Tissue Toxicity in Patients Treated with Accelerated Radiotherapy

Authors

  • Christopher R. Wratten From the Newcastle Mater Hospital, Waratah, NSW (C.R. Wratten) and the Queensland Radium Institute, Brisbane (M.G. Poulsen, S. Williamson, L. Tripcony, J. Keller, G. Dickie), Australia
  • Michael G. Poulsen From the Newcastle Mater Hospital, Waratah, NSW (C.R. Wratten) and the Queensland Radium Institute, Brisbane (M.G. Poulsen, S. Williamson, L. Tripcony, J. Keller, G. Dickie), Australia
  • Steve Williamson From the Newcastle Mater Hospital, Waratah, NSW (C.R. Wratten) and the Queensland Radium Institute, Brisbane (M.G. Poulsen, S. Williamson, L. Tripcony, J. Keller, G. Dickie), Australia
  • Lee Tripcony From the Newcastle Mater Hospital, Waratah, NSW (C.R. Wratten) and the Queensland Radium Institute, Brisbane (M.G. Poulsen, S. Williamson, L. Tripcony, J. Keller, G. Dickie), Australia
  • Jacqui Keller From the Newcastle Mater Hospital, Waratah, NSW (C.R. Wratten) and the Queensland Radium Institute, Brisbane (M.G. Poulsen, S. Williamson, L. Tripcony, J. Keller, G. Dickie), Australia
  • Graeme Dickie From the Newcastle Mater Hospital, Waratah, NSW (C.R. Wratten) and the Queensland Radium Institute, Brisbane (M.G. Poulsen, S. Williamson, L. Tripcony, J. Keller, G. Dickie), Australia

DOI:

https://doi.org/10.1080/028418602317314073

Abstract

The aim of this study was to assess the effect of surgery on normal tissue toxicity in head and neck cancer patients treated with accelerated radiotherapy. Toxicity data from two trials of accelerated radiotherapy were compared. The first group was taken from a phase III trial of definitive radiotherapy and the second group from a phase II trial of postoperative radiotherapy. The general eligibility criteria (apart from surgery), data collection and radiotherapy details for both trials were similar. The definitive group included 172 eligible patients and the postoperative group 52 eligible patients. At 3 weeks into treatment, by which time the dose and rate of dose accumulation were identical, there was no difference in acute toxicity. Analysis of late toxicity showed greater subcutaneous fibrosis in the postoperative group.

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Published

2002-01-01

How to Cite

Wratten, C. R., Poulsen, M. G., Williamson, S., Tripcony, L., Keller, J., & Dickie, G. (2002). Effect of Surgery on Normal Tissue Toxicity in Patients Treated with Accelerated Radiotherapy. Acta Oncologica, 41(1), 56–62. https://doi.org/10.1080/028418602317314073

Issue

Vol. 41 No. 1 (2002): Acta Oncologica

Section

Articles