Expression of Bcl-2 Family Members in Malignant Pleural Mesothelioma

Authors

  • Sara L. O'Kane Postgraduate Medical Institute of the University of Hull and Hull York Medical School, University of Hull, UK
  • Rachelle J. Pound Postgraduate Medical Institute of the University of Hull and Hull York Medical School, University of Hull, UK
  • Anne Campbell Histopathology, Hull Royal Infirmary, Hull, UK
  • Nilanjan Chaudhuri Postgraduate Medical Institute of the University of Hull and Hull York Medical School, University of Hull, UK
  • Michael J. Lind Postgraduate Medical Institute of the University of Hull and Hull York Medical School, University of Hull, UK
  • Lynn Cawkwell Postgraduate Medical Institute of the University of Hull and Hull York Medical School, University of Hull, UK

DOI:

https://doi.org/10.1080/02841860500468927

Abstract

Little is known about the Bcl-2 family members in mesothelioma. These proteins are involved in the control of apoptosis, carrying out both pro- and anti- apoptotic functions. Immunohistochemistry was used to examine the expression of p53 and Bcl-2 family members in 54 archival mesothelioma samples (39 epithelial, 15 sarcomatoid tumours). Overexpression of p53 was observed in 81% (44/54). For anti-apoptotic proteins, overexpression was recorded as follows: Bcl-2 40% (22/54), Bcl-XL 24% (13/54), Mcl-1 92% (50/54). For pro-apoptotic proteins, loss of expression was recorded as follows: Bad 25% (14/54), Bak 24% (13/54), Bax 42% (23/54), Bid 37% (20/54), Bim 18% (10/54). Statistically significant differences between epithelial and sarcomatoid tumours were observed for Bid (p < 0.001), Bad (p = 0.012) and Bcl-XL (p = 0.03). Significant differences in abnormal expression of apoptosis proteins were found between epithelial and sarcomatoid subtypes but histological subtype was the only factor with significant association to patient prognosis.

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Published

2006-01-01

How to Cite

O’Kane, S. L., Pound, R. J., Campbell, A., Chaudhuri, N., Lind, M. J., & Cawkwell, L. (2006). Expression of Bcl-2 Family Members in Malignant Pleural Mesothelioma. Acta Oncologica, 45(4), 449–453. https://doi.org/10.1080/02841860500468927

Issue

Vol. 45 No. 4 (2006): Acta Oncologica

Section

Articles