Radioresponse of Thymomas Verified with Histologic Response

Authors

  • Kiyoshi Ohara From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)
  • Hideo Tatsuzaki From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)
  • Hiroshi Fuji From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)
  • Shinji Sugahara From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)
  • Toshiyuki Okumura From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)
  • Eiichi Akaogi From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)
  • Masataka Onizuka From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)
  • Shigemi Ishikawa From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)
  • Kiyofumi Mitsui From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)
  • Yuji Itai From the Departments of Radiology (K. Ohara, H. Tatsusaki, H. Fuji, T. Okumura, Y. Itai) and Surgery (E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui), Tsukuba University Hospital, the Institute of Clinical Medicine (K. Ohara, H. Tatsuzaki, T. Okumura, E. Akaogi, M. Onizuka, S. Ishikawa, K. Mitsui, Y. Itai), University of Tsukuba, Tsukuba City, and the Department of Radiology, Hitachi General Hospital, Hitachi City, Japan (S. Sugahara)

DOI:

https://doi.org/10.1080/028418698430421

Abstract

Patterns of radiologic response of 10 thymomas treated by preoperative radiotherapy (RT) (18-20 Gy/2 weeks) were determined in conjunction with histologic response. Changes in tumor volume were evaluated with CT scans obtained 5 to 36 days before and 14 to 24 days after the initiation of RT and before surgery. The extent of tumor volume reduction (TR) varied widely (40-78%), while the mean daily volume decrement expressed as a percentage of the pre-RT tumor volume correlated significantly with the pre-RT tumor volume. Histologically, the tumors, all of which were resected 17 to 33 days after RT initiation, generally consisted of predominant fibrous tissues, rare necrotic foci, and few epithelial cells. The TR did not correlate with pre-RT tumor volume, observation period, histologic subtype, or quantity of remaining epithelial cells. The TR of thymomas does not predict RT impact on tumor cells but does reflect the quantity of inherent tumor stroma.

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Published

1998-01-01

How to Cite

Ohara, K., Tatsuzaki, H. ., Fuji, H., Sugahara, S. ., Okumura, T. ., Akaogi, E. ., … Itai, Y. . (1998). Radioresponse of Thymomas Verified with Histologic Response. Acta Oncologica, 37(5), 471–474. https://doi.org/10.1080/028418698430421

Issue

Vol. 37 No. 5 (1998): Acta Oncologica

Section

Articles