Treatment of Lethal Midline Granuloma Type Nasal T-Cell Lymphoma

Authors

  • Kohichi Sakata Department of Radiology, Sapporo Medical University, School of Medicine, Sapporo, Japan
  • Masato Hareyama Department of Radiology, Sapporo Medical University, School of Medicine, Sapporo, Japan
  • Atushi Ohuchi Department of Radiology, Sapporo Medical University, School of Medicine, Sapporo, Japan
  • Mitsuo Sido Department of Radiology, Sapporo Medical University, School of Medicine, Sapporo, Japan
  • Hisayasu Nagakura Department of Radiology, Sapporo Medical University, School of Medicine, Sapporo, Japan
  • Kazuo Morita Department of Radiology, Sapporo Medical University, School of Medicine, Sapporo, Japan
  • Yasuaki Harabuchi Department of Otolaryngology, Sapporo Medical University, School of Medicine, Sapporo, Japan
  • Akikatsu Kataura Department of Otolaryngology, Sapporo Medical University, School of Medicine, Sapporo, Japan

DOI:

https://doi.org/10.3109/02841869709001268

Abstract

Nasal T-cell lymphoma of the LMG type (LMG-NTL) is characterized by progressive, unrelenting ulceration, and necrosis of the nasal cavity and midline facial tissues. The clinical behavior of this tumor in 16 patients is compared with that of a nasal lymphoma of non-LMG-NTL type (non-LMG-NTL) in 8 patients and a paranasal sinus lymphoma (PSL) in 6 patients. All patients had stage I or II disease. Fourteen of the 16 patients with LMG-NTL received chemotherapy before and/or after radiotherapy. Cause-specific 5-year survival rates for patients with LMG-NTL, non-LMG-NTL, and PSL were 22%, 75%, and 67%, respectively. Seven patients with LMG-NTL, had complete response, although 3 recurred, whereas it was incomplete in 9 patients. The data indicates that it is desirable to deliver 50 Gy or more to achieve in-field control of LMG-NTL.

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Published

1997-01-01

How to Cite

Sakata, K., Hareyama, M., Ohuchi, A., Sido, M., Nagakura, H., Morita, K., … Kataura, A. (1997). Treatment of Lethal Midline Granuloma Type Nasal T-Cell Lymphoma. Acta Oncologica, 36(3), 307–311. https://doi.org/10.3109/02841869709001268

Issue

Vol. 36 No. 3 (1997): Acta Oncologica

Section

Articles