Kidney and Bladder Cancer in Inuit 1969-1988

Abstract

The incidence of cancers of the kidney and urinary bladder in Inuit 1969-1988 was studied as part of an international collaboration combining results from cancer registries for Circumpolar Inuit residing in Alaska, Canada and Greenland. Significant high risk of renal cancer was found in Inuit women (SIRs 1.4-2.1) and the age-standardized incidence rate among women was one of the highest on record world-wide. Cancer of the urinary bladder, as opposed to renal cancer, was an uncommon malignancy in both sexes with SIRs of 0.2 to 0.4. No consistent time trend was observed for either renal or bladder cancer in contrast to high and sharply increasing lung cancer rates during the same period. Such results are more likely caused by different latency periods for renal and bladder cancer than for lung cancer following tobacco exposure, possibly combined with the absence of certain occupational exposures relevant to bladder cancer.