Advanced Nasopharyngeal Carcinoma and Radiation-Induced Meningioma in Dizygotic Twins—A Rare Case Report

Abstract

Nasopharyngeal carcinoma (NPC) is a rare malignancy in the young. The main treatment approach is high-dose radiotherapy to involved and presumably involved areas of disease. Radiation therapy alone can achieve local control and survival rates of 70-80%, depending primarily on initial stage (mainly lymph node status), total dose and irradiated volume (1). Serious long-term side-effects of wide-field radiation therapy in NPC are rare but may include temporal lobe necrosis, primary and/or secondary panhypopituitarism and cranial nerve palsies. To date, radiation-induced secondary brain tumors have not been described (2).