Serum Tumor Markers for Detection of Bone Metastasis in Breast Cancer Patients

Authors

  • Adnan Aydiner Institute of Oncology, Dept. of Medical Oncology, University of Istanbul, Turkey
  • Erkan Topuz Institute of Oncology, Dept. of Medical Oncology, University of Istanbul, Turkey
  • Rian Discli Istanbul Faculty of Medicine, Dept. of Public Health (in Biostatistics and demography section), University of Istanbul, Turkey
  • Vildan Yasasever Institute of Oncology, Dept. of Basic Sciences, University of Istanbul, Turkey
  • Maktav Dincer Institute of Oncology, Dept. of Radiation Oncology, University of Istanbul, Turkey
  • Koray Dincol Institute of Oncology, Dept. of Medical Oncology, University of Istanbul, Turkey
  • Nijad Bilge Institute of Oncology, Dept. of Radiation Oncology, University of Istanbul, Turkey

DOI:

https://doi.org/10.3109/02841869409098402

Abstract

For the diagnosis of bone metastasis in breast cancer patients during systemic treatment serum tumor markers, including carbohydrate antigens 15–3 (CA 15–3) and 19–9 (CA 19–9), cancer antigen 125 (CA 125), alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), beta-2 microglobulin (BMG), fer-ritin, and tissue polypeptide antigen (determined by the M3 monocolonal antibody, TPS) were measured in 22 patients with known bone metastases and in 30 patients without documented metastases. The most useful single marker was CA 15–3. By stepwise discriminant analysis, it was found that 90% of the patients could be diagnosed truly by using the markers CA 15–3, BMG and ferritin. It is concluded that monitoring with combinations of tumor markers at regular intervals increases the diagnostic efficiency.

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Published

1994-01-01

How to Cite

Aydiner, A., Topuz, E., Discli, R., Yasasever, V., Dincer, M., Dincol, K., & Bilge, N. (1994). Serum Tumor Markers for Detection of Bone Metastasis in Breast Cancer Patients. Acta Oncologica, 33(2), 181–186. https://doi.org/10.3109/02841869409098402

Issue

Vol. 33 No. 2 (1994): Acta Oncologica

Section

Articles