Enhancement of Fast Neutron Beams with Boron Neutron Capture Therapy: A mechanism for achieving a selective, concomitant tumor boost

Authors

  • Thomas A. Buchholz Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
  • George E. Laramore Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
  • Peter Wootton Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
  • John C. Livesey Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
  • D. Scott Wilbur Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
  • Rudolph Risler Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
  • Mark Phillips Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
  • John Jacky Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA
  • Thomas W. Griffin Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA

DOI:

https://doi.org/10.3109/02841869409098422

Abstract

Both fast neutron radiotherapy and boron neutron capture therapy (BNCT) have been utilized to treat malignant disease. Herein we discuss the potential of combining these treatments to enhance the effectiveness of fast neutron therapy through a concomitant BNCT boost. Using a fast neutron beam generated from a 50 MeV proton on beryllium reaction, we have determined that 0.1% of the beam per microgram of boron-10 per gram of tissue (μg/g) can be deposited via BNCT. Our mathematical modeling predicts that BNCT enhancement of our beam will lead to an additional 1–2 logs of tumor cell kill for boron-10 concentrations of 30–50 μg/g. We have validated this via V-79 cell line in vitro measurements. A Poisson model estimation of how this additional cell kill will influence local tumor control, predicts that BNCT enhancement of fast neutron radiation will lead to a clinically significant improvement in outcome.

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Published

1994-01-01

How to Cite

Buchholz, T. A., Laramore, G. E., Wootton, P., Livesey, J. C., Scott Wilbur, D., Risler, R., … Griffin, T. W. (1994). Enhancement of Fast Neutron Beams with Boron Neutron Capture Therapy: A mechanism for achieving a selective, concomitant tumor boost. Acta Oncologica, 33(3), 307–313. https://doi.org/10.3109/02841869409098422

Issue

Vol. 33 No. 3 (1994): Acta Oncologica

Section

Articles