Effects of 8-Chloroadenosine-3′,5′-Monophosphate in Combination with Irradiation in L5178Y Mouse Lymphoblasts

Authors

  • Iwona Buraczewska Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warsaw, Poland
  • Irena Szumiel Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warsaw, Poland
  • Slawomir Zagórski Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warsaw, Poland
  • Georgij G. Afanasjev Department of Radiobiology and Health Protection, Institute of Chemical Physics, Moscow, Russia

DOI:

https://doi.org/10.3109/02841869409121781

Abstract

The effect of a new anticancer drug, 8-chloroadenosine 3′,5′-monophosphate (8-Cl-cAMP-), a site selective cAMP analog, that inhibits growth of cancer cells in vitro, was examined in L5178Y (LY) murine lymphoma cells. Two LY sublines were used, grown in full Fisher's medium: LY-R, radiation resistant and LY-S, radiation sensitive. The latter was also adapted to grow in simplified medium. In the full medium conversion of 8-Cl-cAMP to 8-chloroadenosine presumably was the case of cytotoxicity. In the simplified medium this conversion was limited and the cytotoxic effect much less pronounced. Cytotoxicity was equal in LY-R and LY-S cells and it was not related to changes in the cell cycle distribution; the latter were observed in LY-S, but not in LY-R cells. There was no interaction of the drug with x-rays in LY cells grown either in full or simplified medium.

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Published

1994-01-01

How to Cite

Buraczewska, I., Szumiel, I., Zagórski, S., & Afanasjev, G. G. (1994). Effects of 8-Chloroadenosine-3′,5′-Monophosphate in Combination with Irradiation in L5178Y Mouse Lymphoblasts. Acta Oncologica, 33(6), 671–675. https://doi.org/10.3109/02841869409121781

Issue

Vol. 33 No. 6 (1994): Acta Oncologica

Section

Articles