Urinary Polyamines in Patients with Advanced Cervical Cancer or Pelvic Cancer Recurrence During and After Radiotherapy

Authors

  • Aldo Becciolini University of Florence, Clinical Physiopathology Dept., Section of Radiotherapy, Radiation Biology Laboratory
  • Sauro Porciani University of Florence, Clinical Physiopathology Dept., Section of Radiotherapy, Radiation Biology Laboratory
  • Aldo Lanini University of Florence, Clinical Physiopathology Dept., Section of Radiotherapy, Radiation Biology Laboratory
  • Riccardo Santoni University of Florence, Clinical Physiopathology Dept., Section of Radiotherapy, Radiation Biology Laboratory
  • Luca Cionini University of Florence, Clinical Physiopathology Dept., Section of Radiotherapy, Radiation Biology Laboratory

DOI:

https://doi.org/10.3109/02841869209108180

Abstract

The urinary excretion of polyamines was evaluated before, during and after radiotherapy in 16 patients with advanced squamous cell carcinoma of the uterine cervix (stage IIb or IIIb) and in 7 cases with pelvic recurrence after surgery for various types of carcinoma. The concentration of spermidine was significantly higher in the patients with primary tumors than in those with recurrent tumors. After the first radiation fractions putrescine increased in the patients with primary tumors whereas it decreased in patients with recurrent tumors. The values tended to return to baseline levels with time following treatment initiation. Polyamine increased markedly during treatment in patients who remained disease-free for at least 5 years but not in the patients with progressive disease or relapse. The results suggest a different polyamine metabolism and a different response to radiotherapy of recurrent tumors compared to primary tumors. The increase of urinary polyamines, but not the baseline values, seemed to be correlated to the response after radiotherapy.

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Published

1992-01-01

How to Cite

Becciolini, A., Porciani, S., Lanini, A., Santoni, R., & Cionini, L. (1992). Urinary Polyamines in Patients with Advanced Cervical Cancer or Pelvic Cancer Recurrence During and After Radiotherapy. Acta Oncologica, 31(3), 327–331. https://doi.org/10.3109/02841869209108180