Effects of Roentgen Irradiation on Human Melanoma Metastases in the Skin

Authors

  • R. Salmi Department of Radiotherapy and Oncology, Helsinki University Central Hospital, SF-00290, Helsinki, Finland
  • P. Holsti Department of Radiotherapy and Oncology, Helsinki University Central Hospital, SF-00290, Helsinki, Finland

DOI:

https://doi.org/10.3109/02841868709092975

Keywords:

Therapeutic radiology, malignant melanoma, post-irradiation histology

Abstract

Skin metastases of malignant melanomas in 17 patients were irradiated with three different levels of total dose (40 Gy, 60 Gy and 80 Gy), using a constant fraction size of 5 Gy five times a week. The tumors were removed 10 to 14 days after the last irradiation. The morphologic alterations of the tumor tissue correlated with the total dose. More extensive destruction was seen only after 80 Gy, but even at this level and with this fraction size viable appearing tumor cells remained in all cases. The tumors of one patient exhibited exceptional radiosensitivity. No completely resistant tumor was seen.

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Published

1987-01-01

How to Cite

Salmi, R., & Holsti, P. (1987). Effects of Roentgen Irradiation on Human Melanoma Metastases in the Skin. Acta Oncologica, 26(1), 37–40. https://doi.org/10.3109/02841868709092975

Issue

Vol. 26 No. 1 (1987): Acta Oncologica

Section

Articles