Bone Healing Following Irradiation During Tourniquet Ischaemia

Authors

  • P. Kälebo Laboratory of Experimental Biology, Departments of Anatomy and Handicap Research, the E. N. T. Department of Sahlgrenska Sjukhuset, the Department Of Clinical Oncology and Radiation Therapy, University of Gotheburg and the Institute for Applied Biotechnology, Gothenburg, Sweden
  • M. Jacobsson Laboratory of Experimental Biology, Departments of Anatomy and Handicap Research, the E. N. T. Department of Sahlgrenska Sjukhuset, the Department Of Clinical Oncology and Radiation Therapy, University of Gotheburg and the Institute for Applied Biotechnology, Gothenburg, Sweden
  • T. Albrektsson Laboratory of Experimental Biology, Departments of Anatomy and Handicap Research, the E. N. T. Department of Sahlgrenska Sjukhuset, the Department Of Clinical Oncology and Radiation Therapy, University of Gotheburg and the Institute for Applied Biotechnology, Gothenburg, Sweden
  • I. Turesson Laboratory of Experimental Biology, Departments of Anatomy and Handicap Research, the E. N. T. Department of Sahlgrenska Sjukhuset, the Department Of Clinical Oncology and Radiation Therapy, University of Gotheburg and the Institute for Applied Biotechnology, Gothenburg, Sweden

DOI:

https://doi.org/10.3109/02841868709092980

Keywords:

Radiobiology, rabbits, gamma radiation, bone healing, anoxia

Abstract

The bone harvest chamber (BHC) methodology, a titanium implant for quantitative evaluations of bone healing, was used in order to investigate the radioprotective function of anoxia, in healing bone tissue. After incorporation of one BHC in each proximal tibial metaphysis of a rabbit it was possible to collect newly formed bone specimens in 3-week-periods without animal sacrifice. The amount of bone was determined by microradiography and densitometry. Ten animals divided into 2 groups were used. One group receiving a single dose of 25 Gy during tourniquet ischaemia was compared with another receiving the same dose during normal blood perfusion. A significantly improved bone healing response was seen in the ischaemic group, with a tendency to further improvement with increasing time after irradiation.

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Published

1987-01-01

How to Cite

Kälebo, P., Jacobsson, M., Albrektsson, T., & Turesson, I. (1987). Bone Healing Following Irradiation During Tourniquet Ischaemia. Acta Oncologica, 26(1), 63–68. https://doi.org/10.3109/02841868709092980

Issue

Vol. 26 No. 1 (1987): Acta Oncologica

Section

Articles