Predicted Dose-Volume Isoeffect Curves for Stereotactic Radiosurgery with the 60Co Gamma Unit

Authors

  • J. C. Flicktnger Departments of Radiation Oncology, Neurological Surgery and Radiology, University of Pittsburgh School of Medicine, Joint Radiation Oncology Center, and Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
  • L. D. Lunsford Departments of Radiation Oncology, Neurological Surgery and Radiology, University of Pittsburgh School of Medicine, Joint Radiation Oncology Center, and Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
  • A. Wu Departments of Radiation Oncology, Neurological Surgery and Radiology, University of Pittsburgh School of Medicine, Joint Radiation Oncology Center, and Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
  • A. Kalend Departments of Radiation Oncology, Neurological Surgery and Radiology, University of Pittsburgh School of Medicine, Joint Radiation Oncology Center, and Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA

DOI:

https://doi.org/10.3109/02841869109092387

Keywords:

Stereotactic radiosurgery, brain radiation tolerance linear quadratic, 60Co gamma unit

Abstract

Mathematical models were developed to predict tolerance of brain tissue to stereotactic radiosurgery. the use of these formulas for predicting symptomatic brain necrosis from stereotactic radiosurgery with the Co gamma unit is discussed. Predicted dose-response curves for different collimator sizes were calculated. Dose-volume isoeffect curves for a 3% risk of brain necrosis from a single fraction radiosurgery were then derived. Dose-volume isoeffect curves for combinations of fractionated whole brain irradiation with radiosurgery boosts were also calculated. the predicted dose-volume isoeffect curves provide useful tolerance guidelines for the practice of stereotactic radiosurgery.

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Published

1991-01-01

How to Cite

Flicktnger, J. C., Lunsford, L. D., Wu, A., & Kalend, A. (1991). Predicted Dose-Volume Isoeffect Curves for Stereotactic Radiosurgery with the 60Co Gamma Unit. Acta Oncologica, 30(3), 363–367. https://doi.org/10.3109/02841869109092387

Issue

Vol. 30 No. 3 (1991): Acta Oncologica

Section

Articles