DNA Cytometric and Histologic Findings in Mouse Tumors (BP and S 180) with Different Response to Treatment with Tumor Necrosis Factor

Authors

  • J. Rychly Department of Internal Medicine and the Institute of Pathology, Wilhelm-Pieck-University, Rostock, East Germany
  • E. Knippel Department of Internal Medicine and the Institute of Pathology, Wilhelm-Pieck-University, Rostock, East Germany
  • A. Krygier-Stojalowska Department of Internal Medicine and the Institute of Pathology, Wilhelm-Pieck-University, Rostock, East Germany
  • H. Nizze Department of Internal Medicine and the Institute of Pathology, Wilhelm-Pieck-University, Rostock, East Germany
  • M. Kuchnio Department of Internal Medicine and the Institute of Pathology, Wilhelm-Pieck-University, Rostock, East Germany
  • S.-K. Kraeft Department of Internal Medicine and the Institute of Pathology, Wilhelm-Pieck-University, Rostock, East Germany; Department of Cell Pathology, Institute of Pathology, Pomeranian Medical Academy, Szczecin, Poland

DOI:

https://doi.org/10.3109/02841869009089991

Keywords:

Tumor necrosis factor, mouse tumors, expenmen- tal treatment, DNA cytometry, histology

Abstract

DNA cytometric and histopathologic investigations were performed in two tumor models (BP and S 180) which differed in their sensitivity to tumor necrosis factor (TNF). TNF induced strong necrosis in both tumors, but only the sarcoma 180 showed total regression. After TNF administration DNA cytometry revealed in the BP tumor an increase of cells in the S-phase, and in the S 180 tumor a loss of aneuploid cell populations. Histologic examination revealed a more obvious effect of TNF on tumor blood vessels in BP tumor, whereas infiltration of inflammatory cells was observed only in the S 180 tumor. We concluded that cell infiltration may be of importance for tumor regression and that aneuploid cell populations are more sensitive to TNF treatment than eudiploid cells.

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Published

1990-01-01

How to Cite

Rychly, J., Knippel, E., Krygier-Stojalowska, A., Nizze, H., Kuchnio, M., & Kraeft, S.-K. (1990). DNA Cytometric and Histologic Findings in Mouse Tumors (BP and S 180) with Different Response to Treatment with Tumor Necrosis Factor. Acta Oncologica, 29(1), 47–51. https://doi.org/10.3109/02841869009089991

Issue

Vol. 29 No. 1 (1990): Acta Oncologica

Section

Articles