Results of Treatment in Locally Advanced Carcinoma of the Endometrium

Authors

  • K. Ahmad DEPARTMENTS OF GYNECOLOGIC ONCOLOGY AND RADIATION ONCOLOGY, WAYNE STATE UNIVERSITY, DETROIT; THE DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF MIAMI, MIAMI, USA
  • Y. H. Kim DEPARTMENTS OF GYNECOLOGIC ONCOLOGY AND RADIATION ONCOLOGY, WAYNE STATE UNIVERSITY, DETROIT; THE DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF MIAMI, MIAMI, USA
  • G. Deppe DEPARTMENTS OF GYNECOLOGIC ONCOLOGY AND RADIATION ONCOLOGY, WAYNE STATE UNIVERSITY, DETROIT; THE DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF MIAMI, MIAMI, USA
  • J. Malone DEPARTMENTS OF GYNECOLOGIC ONCOLOGY AND RADIATION ONCOLOGY, WAYNE STATE UNIVERSITY, DETROIT; THE DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF MIAMI, MIAMI, USA
  • A. Herskovic DEPARTMENTS OF GYNECOLOGIC ONCOLOGY AND RADIATION ONCOLOGY, WAYNE STATE UNIVERSITY, DETROIT; THE DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF MIAMI, MIAMI, USA
  • V. Ratanatharathorn DEPARTMENTS OF GYNECOLOGIC ONCOLOGY AND RADIATION ONCOLOGY, WAYNE STATE UNIVERSITY, DETROIT; THE DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF MIAMI, MIAMI, USA
  • W. A. Sakr DEPARTMENTS OF GYNECOLOGIC ONCOLOGY AND RADIATION ONCOLOGY, WAYNE STATE UNIVERSITY, DETROIT; THE DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF MIAMI, MIAMI, USA
  • A. Medina DEPARTMENTS OF GYNECOLOGIC ONCOLOGY AND RADIATION ONCOLOGY, WAYNE STATE UNIVERSITY, DETROIT; THE DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF MIAMI, MIAMI, USA
  • V. Malviya DEPARTMENTS OF GYNECOLOGIC ONCOLOGY AND RADIATION ONCOLOGY, WAYNE STATE UNIVERSITY, DETROIT; THE DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF MIAMI, MIAMI, USA

DOI:

https://doi.org/10.3109/02841869009126546

Keywords:

Endometrial carcinoma, locally advanced, irradiation, combined surgery, radiation

Abstract

The impact of treatment on survival was analyzed in 106 patients with carcinoma of the endometrium stage II (n=61) and stage III (n=45). There was no significant difference in survival in patients with stage II who were treated with radiation theraphy alone or with combination of surgery and radiation therapy. Their five-year actuarial survival was 74.5% and 71.3% respectively (p=≥0.05). However, combined treatment was associated with significantly superior survival in patients with stage III disease where the survival was 57.3% versus 17.5% in patients who received irradiation alone (p=0.01). Diagnosis of stage III disease based upon clinical (CS III) or pathological (PS III) findings was responsible for this difference in survival. Patients with CS III whose tumor could not be resected because of its extent carried poorer prognosis. Patients with stage II had excellent tumor control in pelvis as compared to patients with stage III. Treatment-related complications were minimal. Overall survival of patients with stage 111 was poor (33.8%) due to a high rate of pelvic and/or extrapelvic recurrences.

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Published

1990-01-01

How to Cite

Ahmad, K., Kim, Y. H., Deppe, G., Malone, J., Herskovic, A., Ratanatharathorn, V., … Malviya, V. (1990). Results of Treatment in Locally Advanced Carcinoma of the Endometrium. Acta Oncologica, 29(2), 203–209. https://doi.org/10.3109/02841869009126546

Issue

Vol. 29 No. 2 (1990): Acta Oncologica

Section

Articles