Biological Response In Vitro to Pulsed High Dose Rate Electrons from a Clinical Accelerator

Authors

  • B. U. Zackrisson Departments of Oncology, Radiation Physics, and Statistics, University of Umeå, Sweden
  • U. H. Nyström Departments of Oncology, Radiation Physics, and Statistics, University of Umeå, Sweden
  • P. Ostbergh Departments of Oncology, Radiation Physics, and Statistics, University of Umeå, Sweden

DOI:

https://doi.org/10.3109/02841869109092451

Keywords:

Radiobiology, ultra high dose rate, in vitro, RBE, OER

Abstract

Several studies of biological response to ionizing radiation of high absorbed dose rates have been performed, often with conflicting results. The aim of this study was to establish whether a difference between irradiation at high dose rates and at more conventional dose rates could be verified. Pulsed 50 MeV electrons from a clinical accelerator were used both for the high dose rate experiments (mean dose rate: 3.8 x 102) Gy/s) and the reference experiments (mean dose rate: 9.6 x 10-2 Gy/s). In this study V-79 cells were irradiated in vitro. The experiments were carried out under both oxic and anoxic conditions. No significant difference in relative biological effectiveness (RBE) or oxygen enhancement ratio (OER) was observed at the different dose rates investigated.

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Published

1991-01-01

How to Cite

Zackrisson, B. U., Nyström, U. H., & Ostbergh, P. (1991). Biological Response In Vitro to Pulsed High Dose Rate Electrons from a Clinical Accelerator. Acta Oncologica, 30(6), 747–751. https://doi.org/10.3109/02841869109092451

Issue

Vol. 30 No. 6 (1991): Acta Oncologica

Section

Articles