Inhibitory Effect of Bestatin on the Growth of Human Leukemic Cells

Authors

  • K. Sakurada Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • M. Imamura Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • M. Kobayashi Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • N. Tachibana Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • K. Abe Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • M. Tanaka Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • M. Okabe Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • M. Morioka Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • M. Kasai Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • T. Sugiura Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan
  • T. Miyazaki Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan

DOI:

https://doi.org/10.3109/02841869009093003

Keywords:

Bestatin, leukemic cell lines, [3H]TdR incorporation

Abstract

We examined the effect of bestatin (Ubenimex) on the growth of human leukemic cells (i.e, HL-60, K562, MT-1, MT-2, Molt-4, and Raji cells). The growth of each cell line was inhibited by the cocultivation with bestatin at higher concentrations than employed for clinical use in Japan. [3H]TdR incorporation was also inhibited in MT-1 and MT-2 cells by treatment with bestatin. Degenerated cell-to-cell adhesion was observed among the treated cells. These findings suggest that the inhibitory effect on some leukemic cells, especially on MT-1 cells, results from the inhibition of DNA synthesis.

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Published

1990-01-01

How to Cite

Sakurada, K., Imamura, M., Kobayashi, M., Tachibana, N., Abe, K., Tanaka, M., … Miyazaki, T. (1990). Inhibitory Effect of Bestatin on the Growth of Human Leukemic Cells. Acta Oncologica, 29(6), 799–802. https://doi.org/10.3109/02841869009093003

Issue

Vol. 29 No. 6 (1990): Acta Oncologica

Section

Articles