The Predictive Value of Initial Cytostatic Response in Primary Unresectable Rhabdomyosarcoma in Children

Authors

  • J. Treuner Department of Haematology and Oncology, Paediatric Centre, Olga Hospital, Stuttgart, University Children'S Hospital, Tübingen; Institute for Medical Statistics and Documentation, University of Mainz, Mainz, West Germany
  • J. Suder Department of Haematology and Oncology, Paediatric Centre, Olga Hospital, Stuttgart, University Children'S Hospital, Tübingen; Institute for Medical Statistics and Documentation, University of Mainz, Mainz, West Germany
  • M. Keim Department of Haematology and Oncology, Paediatric Centre, Olga Hospital, Stuttgart, University Children'S Hospital, Tübingen; Institute for Medical Statistics and Documentation, University of Mainz, Mainz, West Germany
  • P. Kaatsch Department of Haematology and Oncology, Paediatric Centre, Olga Hospital, Stuttgart, University Children'S Hospital, Tübingen; Institute for Medical Statistics and Documentation, University of Mainz, Mainz, West Germany
  • D. Niethammer Department of Haematology and Oncology, Paediatric Centre, Olga Hospital, Stuttgart, University Children'S Hospital, Tübingen; Institute for Medical Statistics and Documentation, University of Mainz, Mainz, West Germany

DOI:

https://doi.org/10.3109/02841868909111184

Keywords:

Rhabdomyosarcoma, children, chemotherapy response, prognosis

Abstract

The relation between the initial tumour regression produced by chemotherapy and the later event-free survival was studied in a prospective multicentre study on soft-tissue sarcomas in children. The event-free survival rate in patients with complete remission after seven weeks of chemotherapy was 95%; in patients with incomplete tumour reduction of >2/3, 61%; and in patients with tumour reduction of <2/3 but >1/3, 31 %. Patients with partial remission at week 7, who achieved complete remission by week 16 after additional chemotherapy had an event-free survival rate of 64%. A multivariate analysis suggested that the response per unit of time was an important prognostic factor.

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Published

1989-01-01

How to Cite

Treuner, J. ., Suder, J., Keim, M. ., Kaatsch, P. ., & Niethammer, D. . (1989). The Predictive Value of Initial Cytostatic Response in Primary Unresectable Rhabdomyosarcoma in Children. Acta Oncologica, 28(1), 67–72. https://doi.org/10.3109/02841868909111184

Issue

Vol. 28 No. 1 (1989): Acta Oncologica

Section

Articles