Non-Hodgkin Lymphoma: Multivariate analysis of prognostic factors including fraction of S-phase cells

Authors

  • P. Lenner Department of Oncology, Laboratory of Clinical Cytology, and the Oncologic Centre, University of Umeå, S-90185, Umeå, Sweden
  • G. Roos Department of Oncology, Laboratory of Clinical Cytology, and the Oncologic Centre, University of Umeå, S-90185, Umeå, Sweden
  • H. Johansson Department of Oncology, Laboratory of Clinical Cytology, and the Oncologic Centre, University of Umeå, S-90185, Umeå, Sweden
  • J. Lindh Department of Oncology, Laboratory of Clinical Cytology, and the Oncologic Centre, University of Umeå, S-90185, Umeå, Sweden
  • U. Dige Department of Oncology, Laboratory of Clinical Cytology, and the Oncologic Centre, University of Umeå, S-90185, Umeå, Sweden

DOI:

https://doi.org/10.3109/02841868709091427

Keywords:

Non-Hodgkin lymphoma, prognostic factors, multivariate analysis, DNA analysis, fraction of S-phase cells

Abstract

In a material of 80 patients with non-Hodgkin lymphoma a multivariate analysis was carried out taking the following variables into account: Age, clinical stage, B-symptoms, morphologic diagnosis and fraction of S-phase cells in the tumour determined by flow cytometry. Clinical stage, proportion of cells in the S-phase, and age of the patient were significant independent prognostic factors. Morphologic malignancy grade and B-symptoms were not significant parameters in this analysis. It was concluded that DNA analysis with determination of the fraction of S-phase cells is a valuable complement to morphology in the evaluation of patients with non-Hodgkin lymphoma. In combination with the clinical stage it gives very good discrimination into groups with different prognoses.

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Published

1987-01-01

How to Cite

Lenner, P. ., Roos, G., Johansson, H., Lindh, J., & Dige, U. (1987). Non-Hodgkin Lymphoma: Multivariate analysis of prognostic factors including fraction of S-phase cells. Acta Oncologica, 26(3), 179–183. https://doi.org/10.3109/02841868709091427

Issue

Vol. 26 No. 3 (1987): Acta Oncologica

Section

Articles