Local Anaesthetics Modifying the Dermal Response of Irradiation: An experimental study

Authors

  • L. Ohlsén Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden
  • H. Evers Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden
  • K. Segerstrom Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden
  • E. Hagelqvist Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden
  • S. Graffman Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden

DOI:

https://doi.org/10.3109/02841868709113720

Keywords:

Radiobiology, cutaneous studies, Rabbits, electron beam, local anaesthetics, response modification

Abstract

In a series of experiments in rabbits the dermal reaction, provoked by a single dose or intermittent doses of irradiation, was prevented or modified by topical or parenteral administration of local anaesthetics, compared to irradiated control animals. The topical application of a eutectic lidocaine/prilocaine cream, EMLA 5%, was found to be more effective than intravenously injected lidocaine (Xylocain 1%).

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Published

1987-01-01

How to Cite

Ohlsén, L., Evers, H., Segerstrom, K., Hagelqvist, E., & Graffman, S. (1987). Local Anaesthetics Modifying the Dermal Response of Irradiation: An experimental study. Acta Oncologica, 26(6), 467–476. https://doi.org/10.3109/02841868709113720

Issue

Vol. 26 No. 6 (1987): Acta Oncologica

Section

Articles