Increased Protective Effect of Hypoxia Against Radiation Following Activation of Haemopoiesis with Dextran Sulphate

Authors

  • A. Vacek Institute of Biophysics of the Czechoslovak Academy of Sciences, Brno, Czechoslovakia; The Institute of Medical Radiology, Academy of Medical Sciences of the Ussr, Obninsk, Ussr
  • A. Bartoníčková Institute of Biophysics of the Czechoslovak Academy of Sciences, Brno, Czechoslovakia; The Institute of Medical Radiology, Academy of Medical Sciences of the Ussr, Obninsk, Ussr
  • D. Rotkovská Institute of Biophysics of the Czechoslovak Academy of Sciences, Brno, Czechoslovakia; The Institute of Medical Radiology, Academy of Medical Sciences of the Ussr, Obninsk, Ussr
  • N. A. Zhukova Institute of Biophysics of the Czechoslovak Academy of Sciences, Brno, Czechoslovakia; The Institute of Medical Radiology, Academy of Medical Sciences of the Ussr, Obninsk, Ussr
  • G. F. Palyga Institute of Biophysics of the Czechoslovak Academy of Sciences, Brno, Czechoslovakia; The Institute of Medical Radiology, Academy of Medical Sciences of the Ussr, Obninsk, Ussr

DOI:

https://doi.org/10.3109/02841868609136420

Keywords:

Radiation biology, blood and hematopoietic studies, radiation protection, hypoxia, dextran sulphate

Abstract

The effect of pretreatment of mice with a single injection of dextran sulphate (DS) on the protective capacity of moderate hypoxia was analysed. Dextran sulphate activated haemopoietic stem cell populations, and irradiation under hypoxia one day after DS injection increased the number of haemopoietic stem cells surviving in the bone marrow of the femur, their recovery after irradiation, and the number of endogenous spleen colonies. A moderate hypoxia (15% O2 and 12% O2) significantly reduced the lethal effect of gamma rays in mice after DS injection and increased the value of LD 50/30.

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Published

1986-01-01

How to Cite

Vacek, A., Bartoníčková, A., Rotkovská, D., Zhukova, N. A., & Palyga, G. F. (1986). Increased Protective Effect of Hypoxia Against Radiation Following Activation of Haemopoiesis with Dextran Sulphate. Acta Oncologica, 25(4-6), 285–289. https://doi.org/10.3109/02841868609136420

Issue

Vol. 25 No. 4-6 (1986): Acta Radiologica: Oncology

Section

Articles