DNA Distribution, Cytosol Estrogen Receptors and Axillary Nodes as Prognostic Predictors in Breast Carcinoma

Authors

  • C. `Klintenberg THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, KAROLINSKA INSTITUTET, S-10401, STOCKHOLM; THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, REGIONSJUKHUSET, UNIVERSITY OF LINKöPING, S-58185, LINKöPING, SWEDEN
  • A. Wallgren THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, KAROLINSKA INSTITUTET, S-10401, STOCKHOLM; THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, REGIONSJUKHUSET, UNIVERSITY OF LINKöPING, S-58185, LINKöPING, SWEDEN
  • K. Bjelkenkrantz THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, KAROLINSKA INSTITUTET, S-10401, STOCKHOLM; THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, REGIONSJUKHUSET, UNIVERSITY OF LINKöPING, S-58185, LINKöPING, SWEDEN
  • J. Carstenssen THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, KAROLINSKA INSTITUTET, S-10401, STOCKHOLM; THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, REGIONSJUKHUSET, UNIVERSITY OF LINKöPING, S-58185, LINKöPING, SWEDEN
  • S. Humla THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, KAROLINSKA INSTITUTET, S-10401, STOCKHOLM; THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, REGIONSJUKHUSET, UNIVERSITY OF LINKöPING, S-58185, LINKöPING, SWEDEN
  • B. Nordenskjöld THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, KAROLINSKA INSTITUTET, S-10401, STOCKHOLM; THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, REGIONSJUKHUSET, UNIVERSITY OF LINKöPING, S-58185, LINKöPING, SWEDEN
  • L. Skoog THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, KAROLINSKA INSTITUTET, S-10401, STOCKHOLM; THE DEPARTMENTS OF ONCOLOGY AND PATHOLOGY, REGIONSJUKHUSET, UNIVERSITY OF LINKöPING, S-58185, LINKöPING, SWEDEN

DOI:

https://doi.org/10.3109/02841868509134396

Abstract

One hundred and fifty patients with breast carcinoma were examined to compare axillary node status, estrogen receptor level and cellular DNA content as prognostic indicators. Seventy-four per cent of the patients were postmenopausal and forty per cent had axillary node me-tastases. Estrogen receptor was measured by isoelectric focusing in polyacrylamide gel. DNA was measured in individual cell nuclei by means of Feulgen-acriflavine-sulphate stained imprints. Fifty-two per cent of the tumors had diploid andor tetraploid DNA pattern, and the rest aneuploid pattern. Axillary node metastases, aneuploid DNA pattern and low level of estrogen receptor were related to recurrence. When introduced into Cox's proportional hazards procedure, axillary nodes and estrogen receptor level but not DNA pattern remained as significant predictors of recurrence.

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Published

1986-01-01

How to Cite

`Klintenberg, C., Wallgren, A., Bjelkenkrantz, K., Carstenssen, J., Humla, S., Nordenskjöld, B., & Skoog, L. (1986). DNA Distribution, Cytosol Estrogen Receptors and Axillary Nodes as Prognostic Predictors in Breast Carcinoma. Acta Oncologica, 24(3), 253–258. https://doi.org/10.3109/02841868509134396

Issue

Vol. 24 No. 3 (1985): Acta Radiologica: Oncology

Section

Articles