Orgotein as a Radioprotector in Normal Tissues Experiments on mouse skin and a murine adenocarcinoma

Authors

  • A. Cividalli THE LABORATORY OF DOSIMETRY AND BIOPHYSICS, ENEA CASACCIA, 1-00060, ROME; THE ISTITUTO DI RICERCA CESARE SERONO, 1-00040, ROME, ITALY
  • M. Adami THE LABORATORY OF DOSIMETRY AND BIOPHYSICS, ENEA CASACCIA, 1-00060, ROME; THE ISTITUTO DI RICERCA CESARE SERONO, 1-00040, ROME, ITALY
  • F. De Tomasi THE LABORATORY OF DOSIMETRY AND BIOPHYSICS, ENEA CASACCIA, 1-00060, ROME; THE ISTITUTO DI RICERCA CESARE SERONO, 1-00040, ROME, ITALY
  • L. Palmisano THE LABORATORY OF DOSIMETRY AND BIOPHYSICS, ENEA CASACCIA, 1-00060, ROME; THE ISTITUTO DI RICERCA CESARE SERONO, 1-00040, ROME, ITALY
  • M. C. Pardini THE LABORATORY OF DOSIMETRY AND BIOPHYSICS, ENEA CASACCIA, 1-00060, ROME; THE ISTITUTO DI RICERCA CESARE SERONO, 1-00040, ROME, ITALY
  • M. Spanò THE LABORATORY OF DOSIMETRY AND BIOPHYSICS, ENEA CASACCIA, 1-00060, ROME; THE ISTITUTO DI RICERCA CESARE SERONO, 1-00040, ROME, ITALY
  • F. Mauro THE LABORATORY OF DOSIMETRY AND BIOPHYSICS, ENEA CASACCIA, 1-00060, ROME; THE ISTITUTO DI RICERCA CESARE SERONO, 1-00040, ROME, ITALY

DOI:

https://doi.org/10.3109/02841868509134400

Abstract

The effects of Orgotein (a superoxide dismutase) on the radiation response of normal and malignant murine tissue in vivo were evaluated. The observations were made on the mouse hind leg bearing, in some cases, an adenocarcinoma. The following irradiation protocols were tested: 1) single dose (e.g., 35 and 53 Gy), 2) conventional fractionation (3 Gy/day, 5 days a week) and 3) multiple fractions per day (2×3 Gy/day, 3 h fractionation interval, 5 days a week). Radiation was either delivered alone or preceded by a subcutaneous injection of 20, 100 or 400 mg/kg Orgotein administered 1 or 2 h before the beginning of irradiation. No effects of Orgotein on tumor radiation response were detected. A protective effect on normal tissue was observed when radiation was delivered according to aggressive protocols and a relatively high dosage of Orgotein was administered. Furthermore, an accelerated trend of recovery of normal tissue was observed.

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Published

1985-01-01

How to Cite

Cividalli, A., Adami, M., De Tomasi, F., Palmisano, L., Pardini, M. C., Spanò, M., & Mauro, F. (1985). Orgotein as a Radioprotector in Normal Tissues Experiments on mouse skin and a murine adenocarcinoma. Acta Oncologica, 24(3), 273–277. https://doi.org/10.3109/02841868509134400

Issue

Vol. 24 No. 3 (1985): Acta Radiologica: Oncology

Section

Articles