Alternative Technologies to Generate Monoclonal Antibodies

Authors

  • Torgny Stigbrand Departments of Medical Biochemistry and Biophysics, Diagnostic Radiology, and Gynecological Oncology, University of Umeé, Umeå, Sweden
  • Katrine Riklund åhlström Departments of Medical Biochemistry and Biophysics, Diagnostic Radiology, and Gynecological Oncology, University of Umeé, Umeå, Sweden
  • Birgitta Sundström Departments of Medical Biochemistry and Biophysics, Diagnostic Radiology, and Gynecological Oncology, University of Umeé, Umeå, Sweden
  • Ricardo Makiya Departments of Medical Biochemistry and Biophysics, Diagnostic Radiology, and Gynecological Oncology, University of Umeé, Umeå, Sweden
  • Ulf Stendahl Departments of Medical Biochemistry and Biophysics, Diagnostic Radiology, and Gynecological Oncology, University of Umeé, Umeå, Sweden

DOI:

https://doi.org/10.3109/02841869309096144

Abstract

Several new technologies to generate and modify established hybridomas that produce monoclonal antibodies have recently been presented and further development should make them more suitable for diagnostic and therapeutic techniques. Different proteolytic procedures have been used for the fragmentation of intact antibodies to Fab'2 and Fab fragments and recombinant DNA techniques have made it possible to obtain chimeric, humanized, Fv fragments and single-chain Fvs. A review of the new approaches is presented and the future implications are discussed.

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Published

1993-01-01

How to Cite

Stigbrand, T., Riklund åhlström, K., Sundström, B., Makiya, R., & Stendahl, U. (1993). Alternative Technologies to Generate Monoclonal Antibodies. Acta Oncologica, 32(7-8), 841–844. https://doi.org/10.3109/02841869309096144

Issue

Vol. 32 No. 7-8 (1993): Acta Oncologica

Section

Articles