Distressed personality is associated with late adverse effects in long-term survivors of Hodgkin lymphoma

Authors

  • Alv A. Dahl National Advisory Unit for Late Effects after Cancer Therapy, Oslo University Hospital, Oslo, Norway https://orcid.org/0000-0002-6849-2756
  • Knut B. Smeland National Advisory Unit for Late Effects after Cancer Therapy, Oslo University Hospital, Oslo, Norway; Department of Oncology, Oslo University Hospital, Oslo, Norway https://orcid.org/0000-0002-9832-4032
  • Siri Eikeland National Advisory Unit for Late Effects after Cancer Therapy, Oslo University Hospital, Oslo, Norway; Department of Oncology, Oslo University Hospital, Oslo, Norway
  • Unn-Merete Fagerli Department of Oncology, St Olav’s Hospital, Trondheim, Norway; Institute of Clinical and Molecular Medicine, NTNU, Trondheim, Norway
  • Hanne S. Bersvendsen Department of Oncology, University Hospital of Northern Norway, Tromsø, Norway
  • Alexander Fosså Department of Oncology, Oslo University Hospital, Oslo, Norway; KG Jebsen Centre for B-cell malignancies, University of Oslo, Oslo, Norway
  • Cecilie E. Kiserud National Advisory Unit for Late Effects after Cancer Therapy, Oslo University Hospital, Oslo, Norway; Department of Oncology, Oslo University Hospital, Oslo, Norway

DOI:

https://doi.org/10.2340/1651-226X.2024.40312

Keywords:

Hodgkin lymphoma, Cancer survivors, type D personality, Late adverse effects

Abstract

Background and purpose: There are few studies of personality traits in long-term Hodgkin lymphoma survivors (HLSs) treated according to contemporary stage-and risk-adapted approaches. The Distressed Personality (DP) Scale covers negative affectivity and social inhibition. We examined differences in self-reported late adverse effects (LAEs) between HLSs with and without DP and other explanatory variables.

Material and methods: This cross-sectional questionnaire-based study included a population-based cohort of HLSs treated from 1997 to 2006, aged 8–49 years at diagnosis, and alive in 2016. Among 518 eligible HLSs, 303 responded (58%), and 294 completed the DP scale. DP was defined by scores above cut-off on both the negative affectivity and social inhibition subscales. LAEs studied were major depression, posttraumatic stress disorder, sleep problems, obesity, neuropathy, fatigue, memory problems, and general health. DP and 10 other explanatory variables were tested against LAEs as dependent variables in multivariable regression analyses.

Results: The mean age at survey was 45.9 years (standard deviation [SD] 4.6), mean follow-up time 16.7 years (SD 3.0), and 48% were females. Eighty-two HLSs had DP (28%, 95% confidence interval 23% – 33%). All LAEs except obesity were significantly more common/had higher mean score in HLSs with DP. In multivariable analyses, presence of DP was significantly associated with all LAEs except obesity.

Interpretation: The presence of DP is common among HLSs. The presence of DP was associated with most self-report LAEs examined. Including assessment of personality traits in the survivorship care plans of HLSs should be considered. Prospective studies assessing the influence of pretreatment DP on LAEs are warranted.

Downloads

Download data is not yet available.

References

Holland JC, Weiss Wiesel T. History of psycho-oncology in Psycho-Oncology, Third edition (eds. Holland JC, Breitbart WS, Butow PN, Jacob-sen PB., Loscalzo MJ, McCorkle R). Oxford: Oxford University Press, 2015. p. XXV–XXXV.

Costa PT, McCrae RR, Löckenhoff CE. Personality across the life span. Annu Rev Psychol. 2019;70:423–48.

https://doi.org/10.1146/annurev-psych-010418-103244

Roberts BW, Yoon HJ. Personality psychology. Annu Rev Psychol. 2022;73:489–516.

https://doi.org/10.1146/annurev-psych- 020821-114927

Kiserud CE, Dahl AA, Fosså SD. Cancer survivorship in adults. Recent Res Cancer Res. 2018;210:123–43.

https://doi.org/10.1007/978-3-319-64310-6_8

Denollet J. DS14: standard assessment of negative affectivity, social inhibition, and type D personality. Psychosom Med. 2005;67(1):89–97.

https://doi.org/10.1097/01.psy.0000149256.81953.49

Mols F , Oerlemans S, Denollet J, Roukema J-A, van de Poll-Franse LV. Type D personality is associated with increased comorbidity burden and health care utilization among 3080 cancer survivors. Gen Hosp Psychiatry. 2012;34(4):352–59.

https://doi.org/10.1016/j.genhosppsych.2012.01.014

Mols F, Thong MSY, van de Poll-Franse LV, Roukema JA, Denollet J. Type D (distressed) personality is associated with poor quality of life and mental health among 3080 cancer survivors. J Affect Dis. 2012;136(1–2):26–34.

https://doi.org/10.106/j.jad.2011.08.034

Husson O, Vissers PA, Denollet J, Mols F. The role of personality in the course of health-related quality of life and disease-specific health status among colorectal cancer survivors: a prospective population-based study from the PROFILES registry. Acta Oncol. 2015;54(5):669–77.

https://doi.org/10.3109/0284186X.2014.996663

Husson O, Denollett J, Ezendam NPM, Mols F. Personality, health behaviors, and quality of life among colorectal cancer survivors: results from the PROFILES registry. J Psychosoc Oncol. 2017;35(1):61–76.

https://doi.org/10.1080/07347332.20161226227

Brice P, de Kerviler E, Friedberg JW. Classical Hodgkin lymphoma. Lancet. 2021;398(10310):1518–27.

https://doi.org/10.1016/S0140- 6736(20)32207-8

Ng AK, van Leeuwen FE. Hodgkin lymphoma: late effects of treatment and guidelines for surveillance. Semin Hematol. 2016;53(3):209–15.

https://doi.org/10.1053/j.seminhematol.2016.05.008

Behringer K, Goergen H, Müller H, Thielen I, Brillant C, Kreissl S, et al. Cancer-related fatigue in patients with and survivors of Hodgkin lymphoma: the impact of treatment outcome and social reintegration J Clin Oncol. 2016;34(36):4329–37.

https://doi.org/10.1200/JCO.2016.67.7450

Eikeland SA, Smeland KB, Simensen VC, Fagerli U-M, Bersvendsen HS, Kiserud CE, et al. Chronic fatigue in long-term survivors of Hodgkin’s lymphoma after contemporary risk-adapted treatment. Acta Oncol. 2023;62(1):80–8.

https://doi.org/10.1080/0284186X.2023.2168215

van Leeuwen FE, Ng AK. Long-term risk of second malignancy and cardiovascular disease after Hodgkin lymphoma treatment. Hematology Am Soc Hematol Educ Program. 2016;2016(1);323–30.

https://doi.org/10.1182/asheducation-2016.1.323

de Vries S, Schaapveld M, van Nimwegen FA, Józwiak K, Lugtenburg PJ, Daniëls LA, et al. High burden of subsequent malignant neoplasms and cardiovascular disease in long-term Hodgkin lymphoma survivors. Br. J Cancer. 2018;118(6):887–95.

https://doi.org/10.1038/bjc.2017.476.

Eikeland SA, Smeland KB, Mols F, Fagerli U-M, Bersvendsen HS, Kiserud CE, et al. Chemotherapy-induced peripheral neuropathy after modern treatment of Hodgkin’s lymphoma: symptom burden and quality of life. Acta Oncol. 2021;60(7):911–20.

https://doi.org/10.1080/0284186X.2021.1917776

Chalder T, Berelowitz G, Pawlikowska T, Watts S, Wessely S, Wright D, et al. Development of a fatigue scale. J Psychosom Res. 1993;37(2):147–53.

https://doi.org/10.1016/0022-3999(93)90081-p

Dahl AA, Grotmol KS, Hjermstad MJ, Kiserud CE, Loge JH. Norwegian reference data on the Fatigue Questionnaire and the Patient Health Questionnaire-9 and their interrelationship. Ann Gen Psychiatry. 2020;19:60. https://doi/10.1186/s12991-020-00311-5

Thoresen S, Tambs K, Hussain A, Heir T, Johansen VA, Bisson JI. Brief measure of posttraumatic stress reactions: impact of Event Scale-6. Soc Psychiatry Psychiatr Epidemiol. 2010;45(3):405–12.

https://doi.org/10.1007/s00127-009-0073-x

Kroenke K, Spitzer RL, Williams JBW. The PHQ-9: validity of a brief depression severity measure. J Intern Med. 2001;16(9):606–13.

https://doi.org/10.1046/j.1525-1497.2001.016009606.x

Almkvist O, Bosnes O, Bosnes I, Stordal E. Selective impact of disease on short-term and long-term components of self-reported memory: a population-based HUNT study. BMJ Open. 2017;7:e013586.

https://doi.org/10.1136/bmjopen-2016-013586

Postma TJ, Aaronson NK, Helmans JJ, Muller MJ, Hildebrand JG, Delattre JY, et al. The development of an EORTC quality of life question-naire to assess chemotherapy-induced peripheral neuropathy: the QLQ-CIPN20. Eur J Cancer. 2005;41(8):1135–39.

https://doi.org/10.1016/j.ejca.2005.02.012

Kieffer JM, Postma TJ, van de Poll-Franse L, Mols F, Heimans JJ, Cavaletti, et al. Evaluation of the psychometric properties of the EORTC chemotherapy-induced peripheral neuropathy questionnaire (QLQ-CIPN20). Qual Life Res. 2017;26(11):2999–3010.

https://doi.org/10.1007/s11136-017-1626-1

Jacobsen EL, Bye A, Aass N, Fosså SD, Grotmol K, Kaasa S, et al. Norwegian reference values for the Short-Form Health Survey 36: devel-opment over time. Qual Life Res. 2018;27(5):1201–12.

https://doi.org/10.1007/s11136-017-1684-4

Sangha O, Stucki G, Liang MH, Fossel AH, Katz JN. The Self-administered Comorbidity Questionnaire: a new method to assess comorbidity for clinical and health services research. Arthritis Rheum. 2003;49(2):156–63.

https://doi.org/10.1002/art.10993.

Einvik G, Dammen T, Namtvedt SK, Hrubos-Strøm H, Randby A, Kristiansen HA, et al. Type D personality is associated with increased prevalence in community-residing persons without coronary heart disease. Prevent Cardiol. 2014;21(5):592–600.

https://doi.org/10.1177/2047487312462800

Mols F, Denollet J. Type D personality in the general population: a systematic review of health status, mechanisms of disease, and work-related problems. Health Qual Life Outcomes. 2010;8:9.

https://doi.org/10.1186/1477-7525-8-9

Jacob A, Thyagarajan B, Priyadarshini Kumar M , Shaikh N , Sharon D. Cardiovascular effects of Hodgkin’s lymphoma: a review of litera-ture. J Cancer Res Clin Oncol. 2018;144(1):99–107.

https://doi.org/10.1007/s00432-017-2560-x

Minoia C, Gerardi C, Allocati E, Daniele A, De Sanctis V, Bari A, et al. The impact of healthy lifestyles on late sequelae in classical Hodgkin lymphoma and diffuse large B-cell lymphoma survivors. A systematic review by the Fondazione Italiana Linfomi. Cancers. 2021;13:3135.

https://doi.org/10.3390/cancers13133135

Brunes A, Augestad LB, Gudmundsdottir SL. Personality, physical activity, and symptoms of anxiety and depression: the HUNT study. Soc Psychiatry Psychiatr Epidemiol. 2013;48(5):745–56.

https://doi.org/10.1007/s00127-012-0594-6

Caille P, Stephan Y, Sutin AR, Luchetti M , Canada B, Heraud N, et al. Personality and change in physical activity across 3–10 years. Psychol Health. 2024;39:670–690.

https://doi.org/10.1080/08870446.2022.2092866

Bleidorn W, Hill PL, Back MD, Denissen JJA, Hennecker M, Hopwood CJ, et al. The policy relevance of personality traits. Am Psychol. 2019;74(9):1056–67.

https://doi.org/10.1037/amp0000503

Cherrier MM, Higano CS, Gray HJ. Cognitive skill training improves memory, function, and use of cognitive strategies in cancer survivors. Support Care Cancer. 2022;30(1):711–20.

https://doi.org/10.1007/s00520-021-06453-w

Coyne JC, de Voogd JN. Are we witnessing the decline effect in the Type D personality literature? What can be learned? J Psychosom Res. 2012;73(6):401–7.

https://doi.org/10.1016/j.psychores.2012.09.016.

Downloads

Published

2024-08-04

How to Cite

Dahl, A. A., Smeland, K. B., Eikeland, S., Fagerli, U.-M., Bersvendsen, H. S., Fosså, A., & Kiserud, C. E. (2024). Distressed personality is associated with late adverse effects in long-term survivors of Hodgkin lymphoma. Acta Oncologica, 63(1), 600–606. https://doi.org/10.2340/1651-226X.2024.40312

Issue

Vol. 63 (2024): Acta Oncologica

Section

Original article

Categories

License

Copyright (c) 2023 Alv A. Dahl, Knut B. Smeland, Siri Eikeland, Unn-Merete Fagerli, Hanne S. Bersvendsen, Alexander Fosså, Cecilie E. Kiserud

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.