Transurethral versus open enucleation of the prostate in Sweden – a retrospective comparative cohort study

Authors

DOI:

https://doi.org/10.2340/sju.v58.15327

Keywords:

Benign prostatic obstruction, transurethral enucleation of prostate, transvesical open prostate enucleation, bleeding, surgery time, functional outcomes

Abstract

Objective: To investigate if treatment with transurethral enucleation of the prostate (TUEP) during the learning curve is as efficient and safe in the short term as transvesical open prostate enucleation (OPE), in patients with benign prostatic obstruction (BPO) > 80 ml in a population in Sweden. 

Methods: 54 patients with ultrasound verified BPO > 80 ml and indication for surgery underwent TUEP or OPE between 2013 and 2019. Peri- and postoperative outcome variables regarding voiding efficiency and morbidity from 20 OPE at Skåne University Hospital (SUS) and from the first 34 TUEP performed at SUS and Ystad Hospital were retrospectively assembled. Follow-up data from the first 6 postoperative months were collected by chart review.

Results: Intraoperative bleeding during TUEP was less than in OPE (225 ml vs. 1,000 ml). TUEP took longer surgery time than OPE (210 vs. 150 min.). Within 30 days postoperatively, bleeding occurred less often after TUEP (23% vs. 40%), requiring one fourth of the blood transfusions given after OPE. After TUEP, patients had shorter hospitalisation (3 days vs. 7 days) and catheterisation time (3 days vs. 12 days). During the 6-month follow-up period, incontinence and UTI defined as symtomatic significant bacteriuria (urinary culture) were observed as main complications after TUEP and OPE. Functional outcome data availability (International Prostate Symptom Score [IPSS] questionnaire, uroflowmetry, residual urine) were limited.

Conclusions: Treatment with TUEP during the learning curve led to less bleeding, shorter hospitalisation- and catheterisation time than treatment with OPE. However, surgery time was shorter with OPE. There were no major differences between the groups concerning mid-term functional outcomes, with the reservation of an inconsistent follow-up. 

Downloads

Download data is not yet available.

References

Thomas AW, Cannon A, Bartlett E, et al. The natural history of lower urinary tract dysfunction in men: minimum 10-year urodynamic fol-lowup of transurethral resection of prostate for bladder outlet obstruction. J Urol. 2005 Nov;174(5):1887–91. https://doi.org/10.1097/01.ju.0000176740.76061.24 DOI: https://doi.org/10.1097/01.ju.0000176740.76061.24

Freyer PJ. A clinical lecture on total extirpation of the prostate for radical cure of enlargement of that organ: with four successful cases: delivered at the Medical Graduates’ College, London, June 26th. Br Med J. 1901 Jul 20;2(2116):125–9. https://doi.org/10.1136/bmj.2.2116.125 DOI: https://doi.org/10.1136/bmj.2.2116.125

Millin T. Retropubic prostatectomy; a new extravesical technique; report of 20 cases. Lancet. 1945 Dec 1;2(6380):693–6. https://doi.org/10.1016/S0140-6736(45)91030-0 DOI: https://doi.org/10.1016/S0140-6736(45)91030-0

Herrmann TR, Bach T, Imkamp F, et al. Thulium laser enucleation of the prostate (ThuLEP): transurethral anatomical prostatectomy with laser support. Introduction of a novel technique for the treatment of benign prostatic obstruction. World J Urol. 2010 Feb;28(1): 45–51. https://doi.org/10.1007/s00345-009-0503-0 DOI: https://doi.org/10.1007/s00345-009-0503-0

Fraundorfer MR, Gilling PJ. Holmium:YAG laser enucleation of the prostate combined with mechanical morcellation: preliminary results. Eur Urol. 1998;33(1):69–72. https://doi.org/10.1159/000019535 DOI: https://doi.org/10.1159/000019535

Ahyai SA, Chun FK, Lehrich K, et al. Transurethral holmium laser enucleation versus transurethral resection of the prostate and simple open prostatectomy – which procedure is faster? J Urol. 2012 May;187(5):1608–13. https://doi.org/10.1016/j.juro.2011.12.107 DOI: https://doi.org/10.1016/j.juro.2011.12.107

Gilling PJ, Mackey M, Cresswell M, et al. Holmium laser versus transurethral resection of the prostate: a randomized prospective trial with 1-year followup. J Urol. 1999 Nov;162(5):1640–4. https://doi.org/10.1016/S0022-5347(05)68186-4 DOI: https://doi.org/10.1016/S0022-5347(05)68186-4

Kuntz RM, Lehrich K, Ahyai SA. Holmium laser enucleation of the prostate versus open prostatectomy for prostates greater than 100 grams: 5-year follow-up results of a randomised clinical trial. Eur Urol. 2008 Jan;53(1):160–6. https://doi.org/10.1016/j.eururo.2007.08.036 DOI: https://doi.org/10.1016/j.eururo.2007.08.036

Moody JA, Lingeman JE. Holmium laser enucleation for prostate adenoma greater than 100 gm.: comparison to open prostatectomy. J Urol. 2001 Feb;165(2):459–62. https://doi.org/10.1097/00005392-200102000-00025 DOI: https://doi.org/10.1097/00005392-200102000-00025

Wei HB, Guo BY, Tu YF, et al. Comparison of the efficacy and safety of transurethral laser versus open prostatectomy for patients with large-sized benign prostatic hyperplasia: a meta-analysis of comparative trials. Investig Clin Urol. 2022 May;63(3):262–72. https://doi.org/10.4111/icu.20210281 DOI: https://doi.org/10.4111/icu.20210281

Rao JM, Yang JR, Ren YX, et al. Plasmakinetic enucleation of the prostate versus transvesical open prostatectomy for benign prostatic hyperplasia > 80 mL: 12-month follow-up results of a randomized clinical trial. Urology. 2013 Jul;82(1):176–81. https://doi.org/10.1016/j.urology.2013.02.032 DOI: https://doi.org/10.1016/j.urology.2013.02.032

Geavlete B, Stanescu F, Iacoboaie C, et al. Bipolar plasma enucleation of the prostate vs Open prostatectomy in large benign prostatic hyperplasia cases – a medium term, prospective, randomized comparison. BJU Int. 2013 May;111(5):793–803. DOI: https://doi.org/10.1111/j.1464-410X.2012.11730.x

Herrmann TRW, Gravas S, de la Rosette JJ, et al. Lasers in transurethral enucleation of the prostate-do we really need them. J Clin Med. 2020 May 10;9(5):1412. https://doi.org/10.3390/jcm9051412 DOI: https://doi.org/10.3390/jcm9051412

Herrmann TR. Long-term outcome after endoscopic enucleation of the prostate: from monopolar enucleation to HoLEP and from HoLEP to EEP. Urologe A. 2016 Nov;55(11):1446–54. https://doi.org/10.1007/s00120-016-0245-8 DOI: https://doi.org/10.1007/s00120-016-0245-8

Gu C, Zhou N, Gurung P, et al. Lasers versus bipolar technology in the transurethral treatment of benign prostatic enlargement: a system-atic review and meta-analysis of comparative studies. World J Urol. 2020 Apr;38(4):907–18. https://doi.org/10.1007/s00345-019-02852-1 DOI: https://doi.org/10.1007/s00345-019-02852-1

Li J, Cao D, Huang Y, et al. Holmium laser enucleation versus bipolar transurethral enucleation for treating benign prostatic hyperplasia, which one is better? Aging Male. 2021 Dec;24(1):160–70. https://doi.org/10.1080/13685538.2021.2014807 DOI: https://doi.org/10.1080/13685538.2021.2014807

Che X, Zhou Z, Chai Y, et al. The efficacy and safety of holmium laser enucleation of prostate compared with bipolar technologies in treating benign prostatic hyperplasia: a systematic review and meta-analysis of 10 randomized controlled trials. Am J Mens Health. 2022 Nov-Dec;16(6):15579883221140211. DOI: https://doi.org/10.1177/15579883221140211

Cornu JN, Ahyai S, Bachmann A, et al. A systematic review and meta-analysis of functional outcomes and complications following tran-surethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: an update. Eur Urol. 2015 Jun;67(6):1066–96. https://doi.org/10.1016/j.eururo.2014.06.017 DOI: https://doi.org/10.1016/j.eururo.2014.06.017

Guilianelli R, Gentile B, Albanesi L, et al. Bipolar button transurethral enucleation of prostate in benign prostate hypertrophy treatment: a new surgical technique. Urology 2015. 86:407–14. DOI: https://doi.org/10.1016/j.urology.2015.03.045

Mitropoulos D, Artibani W, Biyani CS, et al. Validation of the Clavien-Dindo grading system in urology by the European Association of Urology guidelines ad hoc panel. Eur Urol Focus. 2018 Jul;4(4): 608–13. https://doi.org/10.1016/j.euf.2017.02.014 DOI: https://doi.org/10.1016/j.euf.2017.02.014

Shah HN, Mahajan AP, Sodha HS, et al. Prospective evaluation of the learning curve for holmium laser enucleation of the prostate. J Urol. 2007 Apr;177(4):1468–74. https://doi.org/10.1016/j.juro.2006.11.091 DOI: https://doi.org/10.1016/j.juro.2006.11.091

Jeong CW, Oh JK, Cho MC, et al. Enucleation ratio efficacy might be a better predictor to assess learning curve of holmium laser enuclea-tion of the prostate. Int Braz J Urol. 2012 May-Jun;38(3):362–71; discussions 372. DOI: https://doi.org/10.1590/S1677-55382012000300009

Gürlen G, Karkin K. Does Holmium laser enucleation of the prostate (HoLEP) still have a steep learning curve? Our experience of 100 con-secutive cases from Turkey. Arch Ital Urol Androl. 2021 Dec 20;93(4):412–7. https://doi.org/10.4081/aiua.2021.4.412 DOI: https://doi.org/10.4081/aiua.2021.4.412

Feng L, Song J, Zhang D, et al. Evaluation of the learning curve for transurethral plasmakinetic enucleation and resection of prostate using a mentor-based approach. Int Braz J Urol. 2017 Mar-Apr;43(2):245–55. DOI: https://doi.org/10.1590/s1677-5538.ibju.2016.0237

Xiong W, Sun M, Ran Q, et al. Learning curve for bipolar transurethral enucleation and resection of the prostate in saline for symptomatic benign prostatic hyperplasia: experience in the first 100 consecutive patients. Urol Int. 2013;90(1):68–74. https://doi.org/10.1159/000343235 DOI: https://doi.org/10.1159/000343235

Neill MG, Gilling PJ, Kennett KM, et al. Randomized trial comparing holmium laser enucleation of prostate with plasmakinetic enucleation of prostate for treatment of benign prostatic hyperplasia. Urology. 2006 Nov;68(5):1020–4. DOI: https://doi.org/10.1016/j.urology.2006.06.021

Zhang K, Sun D, Zhang H, et al. Plasmakinetic vapor enucleation of the prostate with button electrode versus plasmakinetic resection of the prostate for benign prostatic enlargement > 90 ml: perioperative and 3-month follow-up results of a prospective, randomized clinical trial. Urol Int. 2015;95(3):260–4. https://doi.org/10.1159/000381753 DOI: https://doi.org/10.1159/000381753

Li K, Wang D, Hu C, et al. A novel modification of transurethral enucleation and resection of the prostate in patients with prostate glands larger than 80 ml: surgical procedures and clinical outcomes. Urology. 2018 Mar;113:153–9. https://doi.org/10.1016/j.urology.2017.11.036 DOI: https://doi.org/10.1016/j.urology.2017.11.036

Li M, Qiu J, Hou Q, et al. Endoscopic enucleation versus open prostatectomy for treating large benign prostatic hyperplasia: a meta-analysis of randomized controlled trials. PLoS One. 2015 Mar 31;10(3):e0121265. https://doi.org/10.1371/journal.pone.0121265 DOI: https://doi.org/10.1371/journal.pone.0121265

Lin Y, Wu X, Xu A, et al. Transurethral enucleation of the prostate versus transvesical open prostatectomy for large benign prostatic hy-perplasia: a systematic review and meta-analysis of randomized controlled trials. World J Urol. 2016 Sep;34(9):1207–19. https://doi.org/10.1007/s00345-015-1735-9 DOI: https://doi.org/10.1007/s00345-015-1735-9

Gratzke C, Schlenker B, Seitz M, et al. Complications and early postoperative outcome after open prostatectomy in patients with benign prostatic enlargement: results of a prospective multicenter study. J Urol. 2007 Apr;177(4):1419–22. https://doi.org/10.1016/j.juro.2006.11.062 DOI: https://doi.org/10.1016/j.juro.2006.11.062

Published

2023-12-08

How to Cite

Bohlok, J., Söderberg, R. ., & Patschan, O. (2023). Transurethral versus open enucleation of the prostate in Sweden – a retrospective comparative cohort study. Scandinavian Journal of Urology, 58, 126–132. https://doi.org/10.2340/sju.v58.15327

Issue

Section

Original research article