Cutaneous adverse reactions associated to apalumide: two case reports of DRESS syndrome and maculopapular exanthema

Authors

  • Sanna Hallamies Department of Urology, Helsinki University Hospital, Helsinki, Finland
  • Raija Auvinen Department of Infectious Diseases, Inflammation Centre, Helsinki University Hospital and University of Helsink, Helsinki, Finland
  • Heikki Junkkari Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland
  • Nicolas Kluger Department of Dermatology and Allergology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

DOI:

https://doi.org/10.2340/sju.v59.40198

Keywords:

Apalutamide, DRESS, drug reaction, exanthema, prostate cancer

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References

Chi KN, Agarwal N, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, et al. Apalutamide for metastatic, castration-sensitive prostate cancer. J Urol. 2019;202(4):661. https://doi.org/10.1097/01.JU.0000577260.12278.1c DOI: https://doi.org/10.1097/01.JU.0000577260.12278.1c

Smith MR, Saad F, Chowdhury S, Oudard S, Hadaschik BA, Graff JN, et al. Apalutamide treatment and metastasis-free survival in prostate cancer. N Engl J Med. 2018;378(15):1408–18. https://doi.org/10.10.1056/NEJMoa1715546 DOI: https://doi.org/10.1056/NEJMoa1715546

Katayama H, Saeki H, Osada SI. Maculopapular drug eruption caused by apalutamide: case report and review of the literature. J Nippon Med Sch. 2022;89(5):550–4. https://doi.org/10.1272/jnms.JNMS.2022_89-503 DOI: https://doi.org/10.1272/jnms.JNMS.2022_89-503

Shima K, Nomura T, Yamada Y, Usui S, Kobayashi T, Kabashima K. Maculopapular-type drug eruptions caused by apalutamide: case series and a review of the literature. J Eur Acad Dermatology Venereol. 2022;36(2):e113–15. https://doi.org/10.1111/jdv.17657 DOI: https://doi.org/10.1111/jdv.17657

Pan A, Reingold RE, Zhao JL, Moy A, Kraehenbuehl L, Dranitsaris G, et al. Dermatological adverse events in prostate cancer patients treated with the androgen receptor inhibitor apalutamide. J Urol. 2022 May 1;207(5):1010–19. https://doi.org/10.1097/JU.0000000000002425 DOI: https://doi.org/10.1097/JU.0000000000002425

Honda T, Tohi Y, Kaku Y, Kimura N, Kato T, Haba R, et al. Acute generalized exanthematous pustulosis during apalutamide treatment in a patient with prostate cancer. IJU Case Rep. 2022 Nov 1;5(6):497–500. https://doi.org/10.1002/iju5.12525 DOI: https://doi.org/10.1002/iju5.12525

Ducharme O, Sanchez-Pena P, Pham-Ledard A, Beylot-Barry M, Milpied B. The first case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by apalutamide, a novel oral androgen receptor antagonist. Contact Dermatitis. 2022 Apr 1;86(4):313–15. https://doi.org/10.1111/cod.14024 DOI: https://doi.org/10.1111/cod.14024

Martin G, Lambert E, Wang GK. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by apalutamide: a case presentation. Cureus. 2023;15(7):3–7. https://doi.org/10.7759/cureus.41687 DOI: https://doi.org/10.7759/cureus.41687

Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, et al. The DRESS syndrome: a literature review. Am J Med. 2011;124(7):588–97. https://doi.org/10.1016/j.amjmed.2011.01.017 DOI: https://doi.org/10.1016/j.amjmed.2011.01.017

Katsuta M, Nobeyama Y, Hirafuku K, Tashiro K, Kimura T, Asahina A. Characteristics of mild and severe apalutamide-related cutaneous adverse events in patients with prostate cancer: a review of the literature. J Dermatol. 2024;51(1):110–14. https://doi.org/10.1111/1346-8138.16972 DOI: https://doi.org/10.1111/1346-8138.16972

Published

2024-06-13

How to Cite

Hallamies, S., Auvinen, R., Junkkari, H., & Kluger, N. (2024). Cutaneous adverse reactions associated to apalumide: two case reports of DRESS syndrome and maculopapular exanthema. Scandinavian Journal of Urology, 59, 119–120. https://doi.org/10.2340/sju.v59.40198

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Section

Letter to the Editor