Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

Authors

  • Niels Herluf Paulsen Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark; Clinical Pharmacology, Pharmacy and Environmental Medicine Department of Public Health, University of Southern Denmark, Odense, Denmark
  • Camilla Qvortrup Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • Fie Juhl Vojdeman Department of Clinical Biochemistry, Holbaek Hospital, Holbaek, Denmark
  • Peter Plomgaard Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
  • Stig Ejdrup Andersen Clinical Pharmacology Unit, Zealand University Hospital, Roskilde, Denmark
  • Anne Ramlov Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
  • Birgitte Bertelsen Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Maria Rossing Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
  • Claus Gyrup Nielsen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
  • Elke Hoffmann-Lücke Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus N, Denmark; Institute for Clinical Medicine, Aarhus University of Health, Aarhus, Denmark
  • Eva Greibe Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus N, Denmark; Institute for Clinical Medicine, Aarhus University of Health, Aarhus, Denmark
  • Hanne Spangsberg Holm Department of Oncology, Odense University Hospital, Odense, Denmark
  • Heidi Hvid Nielsen Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark
  • Ihab Bishara Yousef Lolas Department of Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark
  • Jonna Skov Madsen Department of Biochemistry and Immunology, Lillebaelt Hospital – University Hospital of Southern Denmark, Vejle, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
  • Marianne Lerbaek Bergmann Department of Biochemistry and Immunology, Lillebaelt Hospital – University Hospital of Southern Denmark, Vejle, Denmark
  • Morten Mørk Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark; Department of Molecular Diagnostics, Aalborg University Hospital, Aalborg, Denmark
  • Palle B. Nielsen Fruekilde Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
  • Pernille Bøttger Department of Biochemistry and Immunology, Lillebaelt Hospital – University Hospital of Southern Denmark, Vejle, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
  • Peter Clausager Petersen Department of Oncology, Zealand University Hospital, Roskilde, Denmark
  • Peter Henrik Nissen Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus N, Denmark; Denmark and Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark
  • Søren Feddersen Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark
  • Troels K. Bergmann Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark; Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark
  • Per Pfeiffer Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark
  • Per Damkier Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark; Clinical Pharmacology, Pharmacy and Environmental Medicine Department of Public Health, University of Southern Denmark, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark

DOI:

https://doi.org/10.1080/0284186X.2022.2132117

Abstract

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Published

2022-11-02

How to Cite

Herluf Paulsen, N., Qvortrup, C., Vojdeman, F. J., Plomgaard, P., Ejdrup Andersen, S., Ramlov, A., … Damkier, P. (2022). Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations. Acta Oncologica, 61(11), 1400–1405. https://doi.org/10.1080/0284186X.2022.2132117

Issue

Vol. 61 No. 11 (2022): Acta Oncologica

Section

Articles