Overweight, obesity and height as risk factors for meningioma, glioma, pituitary adenoma and nerve sheath tumor: a large population-based prospective cohort study

Authors

  • Markus K. H. Wiedmann Department of Neurosurgery, Oslo University Hospital, Ulleval, Oslo, Norway; ;Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia; ;Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
  • Cathrine Brunborg Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway
  • Antonio Di Ieva Neurosurgery Unit, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia
  • Kristina Lindemann Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; ;Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
  • Tom B. Johannesen The Cancer Registry of Norway, Oslo, Norway
  • Lars Vatten Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway
  • Eirik Helseth Department of Neurosurgery, Oslo University Hospital, Ulleval, Oslo, Norway; ;Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
  • John A. Zwart Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; ;FORMI and Department of Neurology, Oslo University Hospital, Ulleval, Oslo, Norway

DOI:

https://doi.org/10.1080/0284186X.2017.1330554

Abstract

Background: In 2016, the International Agency for Research on Cancer (IARC) has announced that avoiding body fatness (i.e. overweight and obesity) contributes to prevent meningioma occurrence, but considered the available evidence for glioma inadequate. The association of body fatness with other CNS tumor subgroups is largely unknown.

Objectives: To assess whether body fatness or body height are associated with risk for meningioma, glioma, pituitary adenoma (PA) or nerve sheath tumor (NST) in a large population-based Norwegian cohort.

Methods: In this prospective cohort study of 1.8 million Norwegian residents, weight and height were measured at baseline and incident intracranial tumors were subsequently identified by linkage to the Cancer Registry of Norway. Cox regression analyses were performed to estimate risk for each tumor subgroup in relation to anthropometric measures, stratified by sex and in different age groups.

Results: During 54 million person-years of follow-up 3335 meningiomas, 4382 gliomas, 1071 PAs and 759 NSTs were diagnosed. Obesity (BMI ≥30 kg/m2) was not associated with risk for meningioma or glioma, but was significantly associated with risk for PA (HR 1.43; 95% CI 1.09–1.88) compared with the reference group (BMI 20–24.9 kg/m2). For intracranial NSTs, obesity was associated with reduced tumor risk (HR 0.68; 95% CI 0.46–0.99). Body height was associated with increased risk for all four tumor subgroups.

Conclusions: This study does not confirm overweight or obesity as risk factors for meningioma. Additionally, overweight and obesity can be quite confidently excluded as risk factors for glioma. However, this study indicates that body fatness increases the risk for PA, while it reduces the risk for NST.

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Published

2017-10-03

How to Cite

Wiedmann, M. K. H. ., Brunborg, C. ., Di Ieva, A. ., Lindemann, K. ., Johannesen, T. B. ., Vatten, L. ., … Zwart, J. A. . (2017). Overweight, obesity and height as risk factors for meningioma, glioma, pituitary adenoma and nerve sheath tumor: a large population-based prospective cohort study. Acta Oncologica, 56(10), 1302–1309. https://doi.org/10.1080/0284186X.2017.1330554

Issue

Vol. 56 No. 10 (2017): Acta Oncologica

Section

Articles