Oxidative stress in non-small cell lung cancer: Role of nicotinamide adenine dinucleotide phosphate oxidase and glutathione

Authors

  • Ilkka K. Ilonen Division of General Thoracic and Esophageal Surgery, Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
  • Jari V. Räsänen Division of General Thoracic and Esophageal Surgery, Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
  • Eero I. Sihvo Division of General Thoracic and Esophageal Surgery, Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland
  • Aija Knuuttila Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
  • Kaisa M. Salmenkivi Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
  • Markku O. Ahotupa MCA Research Laboratory, Department of Physiology, University of Turku, Turku, Finland
  • Vuokko L. Kinnula Department of Medicine, Pulmonary Division, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
  • Jarmo A. Salo Division of General Thoracic and Esophageal Surgery, Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland

DOI:

https://doi.org/10.1080/02841860902824909

Abstract

Background. Cigarette smoke is strongly associated with NSCLC, but the carcinogenesis of NSCLC is poorly understood. Methods. To discover the role of oxidative stress and anti-oxidative defense in NSCLC, we measured NADPH oxidase (NOX) activity, myeloperoxidase activity, 8-OHdG, and glutathione content from lung specimens. These came from 32 patients: 22 NSCLC patients and ten controls without cancer. Results. In NSCLC patients, NOX activity was significantly higher both in the malignant (p = 0.001) and non-malignant (p = 0.044) samples from NSCLC patients, than in the control specimens. Myeloperoxidase activity was lower (p = 0.001) and glutathione content (p = 0.009) higher in malignant tissue. No significant difference was observable in 8-OHdG content between patient groups. Conclusions. Increase in NOX activity in the malignant tissues was independent of smoking history and myeloperoxidase activity, suggesting its independent role in NSCLC pathogenesis.

 

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Published

2009-01-01

How to Cite

Ilonen, I. K., Räsänen, J. V., Sihvo, E. I., Knuuttila, A., Salmenkivi, K. M., Ahotupa, M. O., … Salo, J. A. (2009). Oxidative stress in non-small cell lung cancer: Role of nicotinamide adenine dinucleotide phosphate oxidase and glutathione. Acta Oncologica, 48(7), 1054–1061. https://doi.org/10.1080/02841860902824909

Issue

Vol. 48 No. 7 (2009): Acta Oncologica

Section

Articles