Low Expression of DNA Polymerase β in Human Testicular Germ Cell Tumours: Impact on Foetal Gonocytic Origin Theory

Authors

  • Radosława Nowak From the Department of Molecular Biology, The Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology (R. Nowak, E.A. Grzybowska, A. Wilczyn ska, J.A. Siedlecki) and the Department of Pathology, University Medical School (R. Pykalo), Warsaw, Poland
  • Ewa A. Grzybowska From the Department of Molecular Biology, The Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology (R. Nowak, E.A. Grzybowska, A. Wilczyn ska, J.A. Siedlecki) and the Department of Pathology, University Medical School (R. Pykalo), Warsaw, Poland
  • Anna Wilczyńska From the Department of Molecular Biology, The Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology (R. Nowak, E.A. Grzybowska, A. Wilczyn ska, J.A. Siedlecki) and the Department of Pathology, University Medical School (R. Pykalo), Warsaw, Poland
  • Roman Pykało From the Department of Molecular Biology, The Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology (R. Nowak, E.A. Grzybowska, A. Wilczyn ska, J.A. Siedlecki) and the Department of Pathology, University Medical School (R. Pykalo), Warsaw, Poland
  • Janusz A. Siedlecki From the Department of Molecular Biology, The Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology (R. Nowak, E.A. Grzybowska, A. Wilczyn ska, J.A. Siedlecki) and the Department of Pathology, University Medical School (R. Pykalo), Warsaw, Poland

DOI:

https://doi.org/10.1080/028418602753669580

Abstract

Different models of pathogenesis of adult testicular germ cell tumours (TGCTs) are presented. Analysis of telomeric length and DNA polymerase &#103 expression suggests that seminoma and nonseminoma, two main histological types of TGCTs, derive independently from transformed foetal primordial cells.

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Published

2002-01-01

How to Cite

Nowak, R., Grzybowska, E. A., Wilczyńska, A., Pykało, R., & Siedlecki, J. A. (2002). Low Expression of DNA Polymerase β in Human Testicular Germ Cell Tumours: Impact on Foetal Gonocytic Origin Theory. Acta Oncologica, 41(2), 188–191. https://doi.org/10.1080/028418602753669580

Issue

Vol. 41 No. 2 (2002): Acta Oncologica

Section

Articles