Impact of Highly Active Antiretroviral Therapy in the Treatment of HIV–Infected Patients with Systemic Non-Hodgkin‘s Lymphoma

Authors

  • Otavio C. G. Baiocchi From the Hematology and Transfusion Service (O.C.G. Baiocchi, G.W.B. Colleoni, E.V. Navajas, L.C.C. Duarte, J. Kerbauy, J.S.R. Oliveira), the Department of Pathology (A.C. Alves), Universidade Federal de Sao Paulo, Brazil and the Department of Epidemiology (A.L.S.S. Andrade), Universidade Federal de Goias, UFGGO, Goia nia, Brazil
  • Gisele W. B. Colleoni From the Hematology and Transfusion Service (O.C.G. Baiocchi, G.W.B. Colleoni, E.V. Navajas, L.C.C. Duarte, J. Kerbauy, J.S.R. Oliveira), the Department of Pathology (A.C. Alves), Universidade Federal de Sao Paulo, Brazil and the Department of Epidemiology (A.L.S.S. Andrade), Universidade Federal de Goias, UFGGO, Goia nia, Brazil
  • Eduardo V. Navajas From the Hematology and Transfusion Service (O.C.G. Baiocchi, G.W.B. Colleoni, E.V. Navajas, L.C.C. Duarte, J. Kerbauy, J.S.R. Oliveira), the Department of Pathology (A.C. Alves), Universidade Federal de Sao Paulo, Brazil and the Department of Epidemiology (A.L.S.S. Andrade), Universidade Federal de Goias, UFGGO, Goia nia, Brazil
  • Luiz Claudio C. Duarte From the Hematology and Transfusion Service (O.C.G. Baiocchi, G.W.B. Colleoni, E.V. Navajas, L.C.C. Duarte, J. Kerbauy, J.S.R. Oliveira), the Department of Pathology (A.C. Alves), Universidade Federal de Sao Paulo, Brazil and the Department of Epidemiology (A.L.S.S. Andrade), Universidade Federal de Goias, UFGGO, Goia nia, Brazil
  • Antonio C. Alves From the Hematology and Transfusion Service (O.C.G. Baiocchi, G.W.B. Colleoni, E.V. Navajas, L.C.C. Duarte, J. Kerbauy, J.S.R. Oliveira), the Department of Pathology (A.C. Alves), Universidade Federal de Sao Paulo, Brazil and the Department of Epidemiology (A.L.S.S. Andrade), Universidade Federal de Goias, UFGGO, Goia nia, Brazil
  • Ana Lucia S. S. Andrade From the Hematology and Transfusion Service (O.C.G. Baiocchi, G.W.B. Colleoni, E.V. Navajas, L.C.C. Duarte, J. Kerbauy, J.S.R. Oliveira), the Department of Pathology (A.C. Alves), Universidade Federal de Sao Paulo, Brazil and the Department of Epidemiology (A.L.S.S. Andrade), Universidade Federal de Goias, UFGGO, Goia nia, Brazil
  • Jose Kerbauy From the Hematology and Transfusion Service (O.C.G. Baiocchi, G.W.B. Colleoni, E.V. Navajas, L.C.C. Duarte, J. Kerbauy, J.S.R. Oliveira), the Department of Pathology (A.C. Alves), Universidade Federal de Sao Paulo, Brazil and the Department of Epidemiology (A.L.S.S. Andrade), Universidade Federal de Goias, UFGGO, Goia nia, Brazil
  • Jose Salvador R. Oliveira From the Hematology and Transfusion Service (O.C.G. Baiocchi, G.W.B. Colleoni, E.V. Navajas, L.C.C. Duarte, J. Kerbauy, J.S.R. Oliveira), the Department of Pathology (A.C. Alves), Universidade Federal de Sao Paulo, Brazil and the Department of Epidemiology (A.L.S.S. Andrade), Universidade Federal de Goias, UFGGO, Goia nia, Brazil

DOI:

https://doi.org/10.1080/028418602753669599

Abstract

Twenty cases of systemic non-Hodgkin‘s lymphoma (NHL) in HIV-infected patients were reviewed over a 10-year-period, divided into Group A, including 13 NHL cases treated before the highly active antiretroviral therapy (HAART) era, and Group B, including 7 patients who received HAART. A Kaplan-Meier survival curve was performed and log-rank was applied to assess statistical differences between the groups. In group A, the median CD4 count was 36 cells/mm 3 . No complete remission was found. In group B, the median CD4 count was 137 cells/mm 3 . Four patients (57.0%) are still alive and in complete remission. Group A had a median survival of 5 months and group B 31 months (p=0.0032). Our results are in agreement with recent reports in that a higher CD4 count and better immune status achieved with HAART is predictive of a better outcome. We found that HAART in combination with chemotherapy improves overall survival of NHL patients without increasing adverse effects.

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Published

2002-01-01

How to Cite

Baiocchi, O. C. G., Colleoni, G. W. B., Navajas, E. V., Duarte, L. C. C., Alves, A. C., Andrade, A. L. S. S., … Oliveira, J. S. R. (2002). Impact of Highly Active Antiretroviral Therapy in the Treatment of HIV–Infected Patients with Systemic Non-Hodgkin‘s Lymphoma. Acta Oncologica, 41(2), 192–196. https://doi.org/10.1080/028418602753669599

Issue

Vol. 41 No. 2 (2002): Acta Oncologica

Section

Articles