Cell Cycle Inhibitors and Outcome after Radiotherapy in Bladder Cancer Patients

Authors

  • Ranveig Røtterud From the Departments of Pathology (R. Rotterud, A. Berner, R. Holm), Clinical Research(S.D. FossaE ) and the Centre for Research and Training in Radiotherapy (D.R. Olsen), The Norwegian Radium Hospital, Oslo, Department of Physics, University of Oslo (E.O. Pettersen), Norway
  • Erik O. Pettersen From the Departments of Pathology (R. Rotterud, A. Berner, R. Holm), Clinical Research(S.D. FossaE ) and the Centre for Research and Training in Radiotherapy (D.R. Olsen), The Norwegian Radium Hospital, Oslo, Department of Physics, University of Oslo (E.O. Pettersen), Norway
  • Aasmund Berner From the Departments of Pathology (R. Rotterud, A. Berner, R. Holm), Clinical Research(S.D. FossaE ) and the Centre for Research and Training in Radiotherapy (D.R. Olsen), The Norwegian Radium Hospital, Oslo, Department of Physics, University of Oslo (E.O. Pettersen), Norway
  • Ruth Holm From the Departments of Pathology (R. Rotterud, A. Berner, R. Holm), Clinical Research(S.D. FossaE ) and the Centre for Research and Training in Radiotherapy (D.R. Olsen), The Norwegian Radium Hospital, Oslo, Department of Physics, University of Oslo (E.O. Pettersen), Norway
  • Dag Rune Olsen From the Departments of Pathology (R. Rotterud, A. Berner, R. Holm), Clinical Research(S.D. FossaE ) and the Centre for Research and Training in Radiotherapy (D.R. Olsen), The Norwegian Radium Hospital, Oslo, Department of Physics, University of Oslo (E.O. Pettersen), Norway
  • Sophie D. Fosså From the Departments of Pathology (R. Rotterud, A. Berner, R. Holm), Clinical Research(S.D. FossaE ) and the Centre for Research and Training in Radiotherapy (D.R. Olsen), The Norwegian Radium Hospital, Oslo, Department of Physics, University of Oslo (E.O. Pettersen), Norway

DOI:

https://doi.org/10.1080/028418602320405069

Abstract

The aim of this study was to correlate the expression of cell cycle inhibitors with outcome of patients with muscle-invasive bladder cancer treated with preoperative radiotherapy (46 Gy/4-5 weeks or 20 Gy/1 week) and cystectomy. Patients with pT3b (n=42) or pT0 (n=17) were included in the study. Expression of p16 INK4a and p27 KIP1 was assessed immunohistochemically in pre-radiotherapy biopsies and cystectomy specimens. Previously reported results of p21 CIP1 expression were also included. No difference in pretreatment protein expression was found between patients with pT0 and pT3b. Expression of p21 CIP1 and p27 KIP1 was lower in cystectomy specimens than in pretreatment biopsies. None of the proteins showed significant impact on survival when analysed separately. However, patients with tumours showing >50% expression of p16 INK4a , p21 CIP1 , or p27 KIP1 displayed poorer cancer-specific survival rates compared with the remaining patients (p=0.025). This effect was more pronounced in patients receiving 46 Gy than in those receiving 20 Gy. In conclusion, low expression of cell cycle inhibitors is related to favourable survival after precystectomy radiotherapy.

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Published

2023-11-17

How to Cite

Røtterud, R. ., Pettersen, E. O. ., Berner, A. ., Holm, R. ., Olsen, D. R. ., & Fosså, S. D. . (2023). Cell Cycle Inhibitors and Outcome after Radiotherapy in Bladder Cancer Patients. Acta Oncologica, 41(5). https://doi.org/10.1080/028418602320405069

Issue

Vol. 41 No. 5 (2002): Acta Oncologica

Section

Articles