Phagocytic Activity and Nitric Oxide Production of Circulating Polymorphonuclear Leukocytes from Patients with Peritoneal Carcinomatosis

Authors

  • Dejan Baskic Institute of Microbiology and Immunology, Public Health Institute, Faculty of Medicine, University of Kragujevac, University of Kragujevac, Podgorica
  • Ljubisa Acimovic Institute of Microbiology and Immunology, Public Health Institute, Faculty of Medicine, University of Kragujevac, University of Kragujevac, Podgorica
  • Aleksandar Djukic Institute of Microbiology and Immunology, Public Health Institute, Faculty of Medicine, University of Kragujevac, University of Kragujevac, Podgorica
  • Predrag Djurdjevic Institute of Microbiology and Immunology, Public Health Institute, Faculty of Medicine, University of Kragujevac, University of Kragujevac, Podgorica
  • Suzana Popovic Institute of Microbiology and Immunology, Public Health Institute, Faculty of Medicine, University of Kragujevac, University of Kragujevac, Podgorica
  • Biljana Milicic Institute of Microbiology and Immunology, Public Health Institute, Faculty of Medicine, University of Kragujevac, University of Kragujevac, Podgorica
  • Itana Labovic Institute of Microbiology and Immunology, Public Health Institute, Faculty of Medicine, University of Kragujevac, University of Kragujevac, Podgorica
  • Nebojsa N. Arsenijevic Institute of Microbiology and Immunology, Public Health Institute, Faculty of Medicine, University of Kragujevac, University of Kragujevac, Podgorica

DOI:

https://doi.org/10.1080/02841860310011087

Abstract

Many studies have demonstrated an increase of neutrophils in patients with advanced cancer. However, the possible role of increased neutrophils in various neoplasms studied to date varies considerably. The authors examined the changes in white blood cell counts in patients with peritoneal carcinomatosis. Malonildialdehyde and nitric oxide (NO) plasma and ascitic fluid levels, phagocitic activity and the ability of the polymorphonuclear cells (PMNCs) to produce nitric oxide were also measured. An increase in PMNCs and decrease in lymphocytes was found in cancer patients. Compared with healthy controls, cancer PMNCs showed significant enhancement of phagocytosis. Similarly, pretreatment of healthy PMNCs with crude supernatants from short-term cultures of the peritoneal cells from ascitic fluid of patients with peritoneal carcinomatosis caused marked stimulation of PMNC phagocytosis. In addition, plasma and ascitic fluid nitric oxide levels in cancer patients were significantly higher than those found in control one. Most importantly, it was found that PMNCs from cancer patients release significantly more nitric oxide than corresponding normal controls. Therefore, considering the fact that neutrophils make up more than 50% of total leukocytes, these cells can play one of the most important roles in tumor biology.

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Published

2003-12-01

How to Cite

Baskic, D. ., Acimovic, L. ., Djukic, A. ., Djurdjevic, P. ., Popovic, S. ., Milicic, B. ., … Arsenijevic, N. N. . (2003). Phagocytic Activity and Nitric Oxide Production of Circulating Polymorphonuclear Leukocytes from Patients with Peritoneal Carcinomatosis. Acta Oncologica, 42(8), 846–851. https://doi.org/10.1080/02841860310011087

Issue

Vol. 42 No. 8 (2003): Acta Oncologica

Section

Articles