Therapeutic Outcome of Extranodal NK/T-Cell Lymphoma Initially Treated with Chemotherapy

Authors

  • Byung Su Kim Departments of Internal Medicine and Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul
  • Tae-you Kim Departments of Internal Medicine and Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul
  • Chul Woo Kim Departments of Internal Medicine and Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul
  • Ji Yeun Kim Departments of Internal Medicine and Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul
  • Dae Seog Heo Departments of Internal Medicine and Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul
  • Yung-jue Bang Departments of Internal Medicine and Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul
  • Noe Kyeong Kim Departments of Internal Medicine and Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul

DOI:

https://doi.org/10.1080/02841860310010682

Abstract

The therapeutic outcome of chemotherapy in NK/T cell lymphoma (NTCL) has not been well documented until now. The aims of this study were to investigate the outcome of chemotherapy and to evaluate the clinical factors influencing the responsiveness to chemotherapy. Between 1995 and 2000, 59 patients received anthracycline-based chemotherapy as an initial treatment. Forty-five patients had nasal NTCL, whereas 14 had extranasal NTCL. Forty-one patients had stage I/II and 18 had stage III/IV disease. Epstein-Barr virus status was positive in 67.6% of cases. The results of initial chemotherapy were complete remission in 35.6% of the patients, 2-year disease-free survival in 22.9% and 2-year overall survival in 44.2%. Adjuvant radiotherapy after chemotherapy did not improve outcome in stage I/II nasal NTCL. The International Prognostic Index was a significant prognostic factor of complete remission rate, and stage was also significant for disease-free survival.

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Published

2003-11-01

How to Cite

Su Kim, B., Kim, T.- you, Woo Kim, C., Yeun Kim, J., Seog Heo, D., Bang, Y.- jue, & Kyeong Kim, N. (2003). Therapeutic Outcome of Extranodal NK/T-Cell Lymphoma Initially Treated with Chemotherapy. Acta Oncologica, 42(7), 779–783. https://doi.org/10.1080/02841860310010682

Issue

Vol. 42 No. 7 (2003): Acta Oncologica

Section

Articles