Radiation-induced trismus in the ARTSCAN head and neck trial

Authors

  • Ulrika Lindblom Department of Clinical Sciences, Otorhinolaryngology, Lund University, Lund, Sweden; Department of Otorhinolaryngology, Kirkenes Hospital, Kirkenes, Norway
  • Ola Gärskog Department of Clinical Sciences, Otorhinolaryngology, Umeå University, Umeå, Sweden
  • Elisabeth Kjellén Department of Oncology and Radiation Physics, Skåne University Hospital, Lund University, Lund, Sweden
  • Göran Laurell Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
  • Eva Levring Jäghagen Department of Odontology, Oral and Maxillofacial Radiology, Umeå University, Umeå, Sweden
  • Peter Wahlberg Department of Clinical Sciences, Otorhinolaryngology, Lund University, Lund, Sweden
  • Björn Zackrisson Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
  • Per Nilsson Department of Oncology and Radiation Physics, Skåne University Hospital, Lund University, Lund, Sweden

DOI:

https://doi.org/10.3109/0284186X.2014.892209

Abstract

Trismus, a well-known sequelae after treatment of head and neck cancer, decreases a patient's oral function and quality of life. The main objectives of this study were to: 1) investigate the long-term prevalence of radiation-induced trismus in patients treated for head and neck cancer according to two different fractionation schedules; and 2) model a dose–response relationship for trismus.

Material and methods. Patients were recruited from the Swedish ARTSCAN trial, a prospective randomised multicentre study comparing conventional and accelerated fractionation. A total of 124 patients agreed to a clinical ENT examination 21–127 months (median 66 months) after beginning radiation therapy. Trismus-related scores were assessed using the EORTC H&N35 Quality of Life questionnaire. The TheraBite® range of motion scale was used to measure maximal interincisal distance. The dose–response relationship for structures important for mastication and the temporomandibular joints was investigated by normal tissue complication probability modelling.

Results. No significant differences in patient-reported trismus or maximal interincisal distance were found between the two trial arms. Patient-reported moderate to high scores regarding trismus increased from 3% at the start of radiation therapy to 25% at the long-term follow-up. Maximal interincisal distance correlated significantly with patient-reported scores of trismus. The best dose–response fit to the endpoint data was found for the dose to the ipsilateral masseter.

Conclusions. Trismus is a persistent complication after radiotherapy with 3D-conformal radiation therapy. We found no difference between the severity and prevalence of trismus between conventional and accelerated fractionation, but a significant correlation between the absorbed dose to the mastication structures and opening of the mouth. Further prospective studies may determine whether a reduced dose to structures important for mastication using intensity-modulated radiation therapy will reduce problems with trismus.

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Published

2014-05-01

How to Cite

Lindblom, U., Gärskog, O., Kjellén, E., Laurell, G., Levring Jäghagen, E., Wahlberg, P., … Nilsson, P. (2014). Radiation-induced trismus in the ARTSCAN head and neck trial. Acta Oncologica, 53(5), 620–627. https://doi.org/10.3109/0284186X.2014.892209

Issue

Vol. 53 No. 5 (2014): Acta Oncologica

Section

Articles