Evaluation of an application for intensity-based deformable image registration and dose accumulation in radiotherapy

Authors

  • Maria Thor Department of Medical Physics, Memorial Sloan Kettering Cancer Centre, New York City, New York, USA; Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark
  • Else S. Andersen Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark
  • Jørgen B. B. Petersen Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark
  • Thomas S. Sørensen Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
  • Karsten Ø. Noe Computer Graphics Lab, The Alexandra Institute, Aarhus, Denmark; Department of Computer Science, Aarhus University, Aarhus, Denmark
  • Kari Tanderup Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark
  • Lise Bentzen Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
  • Ulrik V. Elstrøm Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark
  • Morten Høyer Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
  • Ludvig P. Muren Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark

DOI:

https://doi.org/10.3109/0284186X.2014.928742

Abstract

Background. Methods to accurately accumulate doses in radiotherapy (RT) are important for tumour and normal tissues being influenced by geometric uncertainties. The purpose of this study was to investigate a pre-release deformable image registration (DIR)-based dose accumulation application, in the setting of prostate RT.

Material and methods. Initially accumulated bladder and prostate doses were assessed (based on 8–9 repeat CT scans/patient) for nine prostate cancer patients using an intensity-based DIR and dose accumulation algorithm as provided by the Dynamic Adaptive Radiation Therapy (DART) software. The accumulated bladder and prostate dose-volume histograms (DVHs) were compared on a range of parameters (paired Wilcoxon signed-rank test, 5% significance level) to DVHs derived using an in-house developed dose accumulation method based on biomechanical, contour-driven DIR (SurfaceRegistration). Finally, both these accumulated dose distributions were compared to the ‘static’ DVH, assessed from the planning CT.

Results. Over the population, doses accumulated with DART were overall lower than those from SurfaceRegistration (p < 0.05: D2%, gEUD and NTCP (bladder); Dmin (prostate)). The magnitude of these differences peaked for the bladder gEUD with a population median of 47 Gy for DART versus 57 Gy for SurfaceRegistration. Across the ten bladder dose/volume parameters investigated, the most pronounced individual differences were observed between the ‘accumulated’ DVHs and the ‘static’ DVHs, with deviations in mean dose up to 22 Gy.

Conclusion. Substantial and significant differences were observed in the dose distributions between the two investigated DIR-based dose accumulation applications. The most pronounced individual differences were seen for the bladder and relative to the planned dose distribution, encouraging the use of repeat imaging data in RT planning and evaluation for this organ.

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Published

2014-10-01

How to Cite

Thor, M., Andersen, E. S., Petersen, J. B. B., Sørensen, T. S., Noe, K. Ø., Tanderup, K., … Muren, L. P. (2014). Evaluation of an application for intensity-based deformable image registration and dose accumulation in radiotherapy. Acta Oncologica, 53(10), 1329–1336. https://doi.org/10.3109/0284186X.2014.928742

Issue

Vol. 53 No. 10 (2014): Acta Oncologica

Section

Articles