TOP2A and HER2 gene amplification as predictors of response to anthracycline treatment in breast cancer

Authors

  • Kenneth Villman Department of Oncology, Örebro University Hospital, Sweden
  • Johanna Sjöström Department of Oncology, Helsinki University Hospital, Finland
  • Reino Heikkilä Department of Oncology, Rogaland Central Hospital, Stavanger, Norway
  • Ragnar Hultborn Department of Oncology, Sahlgrenska University Hospital, Göteborg, Sweden
  • Per Malmström Department of Oncology, University Hospital Lund, Sweden
  • Nils-Olof Bengtsson Department of Oncology, Umeå University Hospital, Sweden
  • Martin Söderberg Department of Oncology, Central Hospital, Karlstad, Sweden
  • Eero Saksela Department of Pathology, Helsinki University Hospital, Finland
  • Carl Blomqvist Department of Oncology, University Hospital, Uppsala, Sweden

DOI:

https://doi.org/10.1080/02841860500543182

Abstract

The purpose of this study was to evaluate amplification of topoisomerase IIalpha (TOP2A) and HER2 genes as predictors of response to chemotherapy in advanced breast cancer. Gene copy number of TOP2A and HER2 were analysed with chromogenic in situ hybridization (CISH) on paraffin-embedded tissue sections from the primary tumour of 85 patients treated with anthracycline containing chemotherapy. TOP2A gene amplification was present in 14 (16%) and HER2 gene amplification in 38 (45%) of the primary tumours. Two of the 14 cases with TOP2A amplification were amplified without concurrent HER2 amplification. Neither TOP2A nor HER2 gene amplification were significantly associated with response to chemotherapy (p = 0.35 and p = 0.49, respectively).

Downloads

Download data is not yet available.

Downloads

Published

2006-01-01

How to Cite

Villman, K., Sjöström, J., Heikkilä, R., Hultborn, R., Malmström, P., Bengtsson, N.-O., … Blomqvist, C. (2006). TOP2A and HER2 gene amplification as predictors of response to anthracycline treatment in breast cancer. Acta Oncologica, 45(5), 590–596. https://doi.org/10.1080/02841860500543182

Issue

Vol. 45 No. 5 (2006): Acta Oncologica

Section

Articles