Sequential evaluation of hepatic functional reserve by 99mTechnetium-galactosyl human serum albumin scinitigraphy after proton beam therapy: a report of three cases and a review of the literatures

Authors

  • Hiroshi Igaki Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan; Department of Radiation Oncology, University Hospital, University of Tsukuba, Ibaraki, Japan; Department of Radiology, University of Tokyo Hospital, Tokyo, Japan
  • Koichi Tokuuye Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan; Department of Radiation Oncology, University Hospital, University of Tsukuba, Ibaraki, Japan
  • Tohoru Takeda Graduate school of Comprehensive Human Science, University of Tsukuba, Ibaraki, Japan
  • Shinji Sugahara Department of Radiation Oncology, University Hospital, University of Tsukuba, Ibaraki, Japan
  • Masaharu Hata Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan; Department of Radiation Oncology, University Hospital, University of Tsukuba, Ibaraki, Japan
  • Takayuki Hashimoto Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan; Department of Radiation Oncology, University Hospital, University of Tsukuba, Ibaraki, Japan
  • Nobuyoshi Fukumitsu Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan; Department of Radiation Oncology, University Hospital, University of Tsukuba, Ibaraki, Japan
  • Jin Wu Graduate school of Comprehensive Human Science, University of Tsukuba, Ibaraki, Japan
  • Kayoko Ohnishi Department of Radiation Oncology, University Hospital, University of Tsukuba, Ibaraki, Japan
  • Kiyoshi Ohara Department of Radiation Oncology, University Hospital, University of Tsukuba, Ibaraki, Japan
  • Yasuyuki Akine Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan; Department of Radiation Oncology, University Hospital, University of Tsukuba, Ibaraki, Japan

DOI:

https://doi.org/10.1080/02841860600690347

Abstract

The treatment strategy for malignant liver tumors should be appropriately determined because post-treatment quality of life greatly depends on the patients’ residual hepatic function. In this report, we present three patients with malignant liver tumors treated by proton beam therapy in whom pre- and post-therapeutic hepatic functional reserves were evaluated sequentially for more than a year by 99mTechnetium-galactosyl human serum albumin (99mTc-GSA) scintigraphy. All three patients exhibited the distinctive time course of 99mTc-GSA uptake efficiency, which suggested a transient decline in the ratio of liver activity to heart and liver activity at 15 minutes (LHL15) 3–6 months after proton beam therapy. This change was not in parallel with that expected from a functioning normal liver tissue volume. In a year after proton beam therapy, LHL15 recovered nearly to the pre-treatment level in all three patients. Our observations may be related to the up-regulation of receptor-mediated 99mTc-GSA uptake during hepatic regeneration after proton beam therapy.

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Published

2006-01-01

How to Cite

Igaki, H., Tokuuye, K., Takeda, T., Sugahara, S., Hata, M., Hashimoto, T., … Akine, Y. (2006). Sequential evaluation of hepatic functional reserve by 99mTechnetium-galactosyl human serum albumin scinitigraphy after proton beam therapy: a report of three cases and a review of the literatures. Acta Oncologica, 45(8), 1102–1107. https://doi.org/10.1080/02841860600690347

Issue

Vol. 45 No. 8 (2006): Acta Oncologica

Section

Articles